Lipolytic Agents for Submental Fat Reduction: Review
January 2024
in “
Skin research and technology
”
TLDR Deoxycholic acid is FDA-approved for reducing submental fat, but its mechanisms are not fully understood.
The review examines various lipolytic agents for submental fat reduction, focusing on their mechanisms and effectiveness. It highlights deoxycholic acid (DCA), approved as Kybella and V-olet, which disrupts fat cell membranes but has unclear mechanisms. The review notes potential adverse effects like edema, numbness, skin ulcers, and nerve injuries, typically resolving within 3 weeks to 6 months. Off-label uses of DCA for body contouring and lipomas show promise. The study stresses the need for understanding anatomical details and side effects to ensure patient safety and calls for further research on these agents' mechanisms and safety profiles.
