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This study found that a single application of TCDD on the skin of hairless mice altered epidermal differentiation, changing keratin expression patterns similarly to a known tumor promoter.

This review suggests that skin may largely protect itself from CYP-generated reactive metabolites due to higher conjugating enzyme activities, while highlighting limitations in modeling human skin metabolism experimentally.

The new compounds may be more effective and cheaper than current treatments for conditions like baldness.

This study identified potent dual inhibitors of 5α-reductases 1 and 2 that may aid in designing new drugs for related diseases.

This review discusses strategies for treating hormone-dependent prostate diseases and synthesizes a range of potential 5α-reductase inhibitors, but experimental evaluation of these compounds was not completed.

This study explored the potential of using isoenzyme detection after electrophoresis to characterize human hair, though no new clinical results are reported.

This study found that chemical treatments such as hair bleach and UV radiation significantly reduced the amount of 18-methyleicosanoic acid on the outer surface of human hair.

This study found that co-drugs synthesized from hydroquinone and tranexamic acid improved skin targeting and deposition, with reduced irritation and enhanced efficacy for treating hyperpigmentation.

This study found that fentanyl accumulates differently in mouse hair after systemic administration compared to external loading, suggesting ionizable functionalities of hair influence drug retention from organic solutions.

This study found that specific enzymes could be detected in fresh hair sheath cells, with most remaining detectable in older cells, except for Adenylate kinase and Esterase D.

This study found that chemically modifying human hair through esterification or disulfide reduction and alkylation affects the hair's viscoelastic properties, including stability, integrity, and response to moisture.

This study found that a novel thiohydantoin derivative, 3a, effectively inhibited androgen receptor activity in LNCaP cells and showed promising in vivo results by reducing testosterone-induced prostate changes, outperforming finasteride in mitigating prostate index and histopathological alterations.

In this study, the reconstructed skin epidermal model derived from hair follicles showed gene expression and enzyme functionality consistent with native human skin, suggesting its viability for studying skin metabolism and potential toxicity of dermo-cosmetic ingredients.

This study observed that hydrophobic modifications of hair matrix proteins significantly alter the humidity-dependent glass transition temperature of human hair.

This research outlines a chemical synthesis process for Finasteride, detailing the conversion of pregnadienolone acetate through various chemical reactions and modifications.

This study successfully synthesized finasteride using a method that avoids expensive reagents and column chromatography, achieving a higher yield than previously reported.

This study suggests that mouse keratin 6 isoforms, K6a and K6b, have overlapping but distinct expression profiles, differing notably in their expression in suprabasal cells and response to phorbol esters.

This research reported that squarticles, nanoparticles made from sebum-derived lipids, enhanced the follicular delivery and skin accumulation of diphencyprone and minoxidil, indicating effective drug deposition with reduced systemic absorption in alopecia treatment.

This study found that the most likely cause of hypercalcemia in a patient with symptoms of hypervitaminosis A and a history of chronic vitamin A ingestion was vitamin A toxicity.

This review surveys the chemical composition and various uses of jojoba oil in medicine and industry but presents no new clinical results.

This study observed that in Japanese females, hair lipid composition showed significant correlations, suggesting CH and CERs may act as a barrier against sebum-derived lipids.

This study found that in mice, deleting the keratin 10 gene enhances sebocyte differentiation and increases secretion of sebum and certain lipids without affecting proliferation-associated keratins.

This study suggests that Keratin 15 expression in stratified epithelia may be regulated by two distinct mechanisms involving PKC/AP-1 pathway for differentiation and FOXM1 for basal cells, challenging its reliability as a sole stem cell marker.

This study indicates that the normal human prostate is not a major contributor to circulating blood DHT concentrations in androgen-deficient patients receiving testosterone replacement therapy.

This study found that Runx1 in hair follicle stem cells modulates lipid metabolism, impacting membrane organization and enhancing signal transduction for cell proliferation in both normal and cancer epithelial cells.

This review highlights therapeutic options for inducing puberty in males and females with delayed puberty, emphasizing the need for larger trials to establish the best approaches.

Detecting steroid esters in cattle hair is inconsistent and influenced by sampling factors.

This study investigated lipid loss in hair caused by surfactants and found that surface and internal modifications can significantly protect different lipids from depletion, with internal modification preventing 52.0 to 81.3% of lipids in certain groups.

This study found an association between higher phthalate exposure and increased incidence of precocious puberty in girls, suggesting a need to reduce children's exposure to these endocrine disruptors.

This review discusses the role of acyl-CoA binding protein (ACBP) in the epidermal barrier, noting that its disruption in mice is linked to skin and fur abnormalities; it reports no new clinical results.