Studies on Synthesis of Finasteride

    January 2004 in “ Zhōnghuá yàoxué zázhì ”
    Yongzhou Hu
    TLDR The new method for making finasteride is cheaper and gives a higher yield.
    The study focused on synthesizing finasteride through a method that involved opening the ring A of 3-oxo-4-androstene-17β-carboxylic acid with KMnO4-NaIO4, followed by reactions with NH3, hydrogenation with Pd/C, esterification, dehydrogenation, and reaction with t-butylamino magnesium bromide. The structures of intermediates and finasteride were confirmed using IR, 1HNMR, and MS. This synthesis method was successful without the use of expensive reagents like PtO2, (PhSeO)2O, and 2,2′-dipyridyl disulphide, and it did not require column chromatography at any step. The yield of finasteride was significantly higher than previously reported yields.
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