Studies on Synthesis of Finasteride
January 2004
in “
Zhōnghuá yàoxué zázhì
”
New to Finasteride? There is a guide in the encyclopedia. Read the guide → Studysummary This study successfully synthesized finasteride using a method that avoids expensive reagents and column chromatography, achieving a higher yield than previously reported.
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The study focused on synthesizing finasteride through a method that involved opening the ring A of 3-oxo-4-androstene-17β-carboxylic acid with KMnO4-NaIO4, followed by reactions with NH3, hydrogenation with Pd/C, esterification, dehydrogenation, and reaction with t-butylamino magnesium bromide. The structures of intermediates and finasteride were confirmed using IR, 1HNMR, and MS. This synthesis method was successful without the use of expensive reagents like PtO2, (PhSeO)2O, and 2,2′-dipyridyl disulphide, and it did not require column chromatography at any step. The yield of finasteride was significantly higher than previously reported yields.