The Effects of Hydrophobic Modifications on the Interaction of Human Hair with Water

September 2012

I Jinks, Prem K. C. Paul, FJ Wortmann

hydrophobic modifications human hair internal plasticization hypothesis high glycine-tyrosine proteins esterification humidity-dependent glass transition disulphide linkages methylation

TLDR Hydrophobic modifications make human hair less affected by water.

This study explored the effects of hydrophobic modifications on the interaction of human hair with water, focusing on the thermal and mechanical properties of hair. It was based on the "internal plasticization hypothesis," which suggested that high glycine-tyrosine (HGT) proteins in hair have a specific plasticization effect in the matrix. The research involved hydrophobic modifications through esterification, which significantly altered the humidity-dependent glass transition of human hair. Additionally, the study examined the role of disulphide linkages in hair stability by reducing and methylating these linkages, and analyzed the resulting changes in thermal and mechanical properties. Initial findings from this second stage of investigation were reported.

View this study on escholar.manchester.ac.uk →

Discuss this study in the Community →

Related Community Posts Join

6 / 56 results

community Helicobacter's concocted serum v1

7 upvotes 7 years ago

A custom-made serum based on double-blind studies for AGA, which includes natural ingredients such as rosemary oil, procyanidin B-2, saw palmetto extract, curcuma aeruginosa, pumpkin seed oil and castor oil. The user has updated their recipe to include apple poly procyanidin B-2 4% concentration and other ingredients before topping it off with Pura d'or serum.

community Phase II topical dut study - outperforms oral fin with a minor DHT reduction

in Research/Science 61 upvotes 1 month ago

Topical dutasteride 0.05% is more effective for hair growth than oral finasteride 1mg, with minimal DHT reduction. The formulation uses castor oil and MCTs for better absorption but is not widely available until 2028.

community Stacking Fluridil / Topilutamide with other + aqueous topicals?

in Technology 1 upvotes 1 year ago

The conversation discusses how to use fluridil/topilutamide with other hair loss treatments like liquid minoxidil and CB-03-01, considering fluridil's hydrophobic nature and potential degradation with water. The user questions the necessity of washing hair only once per week as suggested by the manufacturer.

community Where the fuck are the pyrilutamide GB guys?

in Chat 23 upvotes 3 years ago

The effects of Pyrilutamide, a hair loss treatment that is being tested for June/July; and reports from people who have experienced side effects similar to those of RU58841, suggesting they may have been sold an incorrect product from their supplier.

community after cosmerna is out will there be another hair loss drug released in 2023?

in Treatment 11 upvotes 2 years ago

User asks if Kintor, HMI-115, or Olix will release hair loss drugs in 2023. Conversation discusses potential treatments and release dates.

community Why is dutasteride's volume of distribution so much bigger than finasteride? Is it more lipophilic and crosses barriers better?

in Finasteride/Dutasteride 24 upvotes 1 year ago

Dutasteride has a larger volume of distribution than finasteride due to its lipophilic nature, allowing it to concentrate in hydrophobic areas and making it difficult to excrete. A user experiencing hair loss has been using oral finasteride for 10 months with minimal regrowth and is considering switching to dutasteride or adding oral minoxidil.

Related Research

1 / 1 results

research The Viscoelastic Properties of Chemically Modified Alpha-Keratins in Human Hair

1 citations , June 2014 in “[Thesis]. Manchester, UK: The University of Manchester; 2014.”

Chemical modifications can alter hair's stability and flexibility, with hydrophobic interactions helping maintain structure in humid conditions.