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GlossarySkin Barrier Function

protects against external threats and prevents water loss

The Skin Barrier Function, also known as the Epidermal Barrier Function, refers to the skin's ability to protect the body from external threats like pathogens, chemicals, and physical injuries, while also preventing excessive water loss. This function is primarily carried out by the outermost layer of the skin, the stratum corneum, which consists of tightly packed dead skin cells and lipids that form a protective barrier.

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research Homozygous ALOXE3 Nonsense Variant Identified in a Patient with Non-Bullous Congenital Ichthyosiform Erythroderma Complicated by Superimposed Bullous Majocchi’s Granuloma: The Consequences of Skin Barrier Dysfunction

16 citations, September 2015 in “International Journal of Molecular Sciences”

A specific gene variant causes severe skin issues and increases infection risk, requiring careful medical monitoring.

research A Novel Animal Model of Desmoglein 1 (Dsg1) Deficiency Reveals an Essential Role for Dsg1 in Epidermal Barrier Formation

April 2018 in “Journal of Investigative Dermatology”

Dsg1 is essential for maintaining a healthy skin barrier in mice.

research LSD1 Is Critical for Epidermal Development and Skin Barrier Formation

April 2023 in “Journal of Investigative Dermatology”

LSD1 is essential for healthy skin development and creating the skin's protective barrier.

research Radiation Dermatitis: Radiation-Induced Effects on the Structural and Immunological Barrier Function of the Epidermis

1 citations, March 2024 in “International journal of molecular sciences”

Radiation therapy damages skin structure and immune function, causing inflammation and potential hair loss.

research Alternative Splicing Factor Esrp1 Controls Homeostasis of Skin by Regulating Barrier Formation and Function

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Esrp1 is important for skin health by helping form and maintain the skin barrier.

research Development of a Novel In Vitro Strategy to Understand the Impact of Shaving on Skin Health: Combining Tape Strip Exfoliation and Human Skin Equivalent Technology

November 2023 in “Frontiers in Medicine”

The method effectively mimics shaving damage on skin for testing skincare products.

research Allergens of Permanent Hair Dyes Induce Epidermal Damage, Skin Barrier Loss, and IL-1 Alpha Increase in Epidermal In Vitro Model

12 citations, December 2017 in “Food and chemical toxicology”

Permanent hair dye mixtures can irritate and damage the skin.

research Delayed Epidermal Permeability Barrier Formation and Hair Follicle Aberrations in Inv-Cldn6 Mice

63 citations, April 2005 in “Mechanisms of development”

Mice with too much Claudin-6 have skin barrier problems and abnormal hair growth.

research Does Dry Skin Indicate Defective Epidermal Permeability Barrier?

October 2022 in “Chinese Journal of Dermatology”

Dry skin does not mean the skin's protective barrier is broken; it's often due to a lack of natural skin moisturizers.

research Stratum Corneum Dysfunction in Dandruff

93 citations, April 2012 in “International Journal of Cosmetic Science”

Improving skin barrier and using antifungal treatments can help manage dandruff.

research Sebaceous Gland, Hair Shaft, and Epidermal Barrier Abnormalities in Keratosis Pilaris with and without Filaggrin Deficiency

23 citations, February 2015 in “The American journal of pathology”

Keratosis pilaris is often linked to genetic mutations and causes skin and hair abnormalities, regardless of those mutations.

research Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin

9 citations, August 2021 in “International journal of molecular sciences”

PPARγ is essential for maintaining healthy skin, controlling inflammation, and ensuring proper skin barrier function.

research Role of Cholesterol Sulfate in Epidermal Structure and Function: Lessons from X-Linked Ichthyosis

87 citations, March 2014 in “Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids”

Cholesterol sulfate buildup due to a genetic mutation disrupts the skin barrier, leading to the scaling skin seen in X-linked ichthyosis.

research The Disintegrin/Metalloproteinase Adam10 Is Essential for Epidermal Integrity and Notch-Mediated Signaling

134 citations, January 2011 in “Development”

Adam10 enzyme is crucial for healthy skin and proper Notch signaling.

research Effect of Hataedock Treatment on Epidermal Structure Maintenance Through Intervention in the Endocannabinoid System

2 citations, January 2020 in “Evidence-based Complementary and Alternative Medicine”

Hataedock treatment improved skin health and reduced atopic dermatitis symptoms by enhancing the skin barrier and reducing inflammation.

research Cyclic Alopecia and Abnormal Epidermal Cornification in Zdhhc13-Deficient Mice Reveal the Importance of Palmitoylation in Hair and Skin Differentiation

16 citations, June 2015 in “The journal of investigative dermatology/Journal of investigative dermatology”

The enzyme DHHC13 is essential for healthy hair and skin, and its deficiency leads to hair loss and skin problems.

research Regulation of Epidermal Proliferation and Hair Follicle Cycling by Synthetic Photostable Retinoid EC23

January 2023 in “Journal of cosmetic dermatology”

The synthetic retinoid EC23 thickens skin and promotes hair growth more effectively and with a lower dose than natural retinoids.

research Single-Cell Transcriptomic Profile of EGFR-Deficient Epidermal Compartments During Folliculitis

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

EGFR deficiency causes significant changes in skin cells and hair follicles.

Skin Barrier, Phenotypic and Genotypic Characterization of Autosomal Recessive Ichthyosis in TGM1-Deficient Jack Russell Terriers and Response to Topical Ceramide

research Skin Barrier, Phenotypic and Genotypic Characterization of Autosomal Recessive Ichthyosis in TGM1-Deficient Jack Russell Terriers and Response to Topical Ceramide

August 2024 in “Veterinary Dermatology”

Topical ceramide treatment partially improves the skin condition in Jack Russell Terriers with a genetic skin disorder.

research The Editor's Choice: Summary of Studies on Skin and Hair Conditions

June 2018 in “Journal of Dermatological Science”

UV radiation may cause DNA changes in skin, certain UVB therapy helps psoriasis, a new gene mutation is linked to mild piebaldism, different immune cells affect psoriasis, a drug promotes hair growth, and some cancer drugs could treat skin barrier issues.

research Inherited Ichthyoses: Generalized Mendelian Disorders of Cornification

81 citations, June 2012 in “European journal of human genetics”

Inherited ichthyoses cause widespread skin scaling and thickening due to gene mutations.

The Regulatory Role of the Tetrapeptide AcSDKP in Skin and Hair Physiology and the Prevention of Aging Effects in These Tissues – A Potential Cosmetic Role

research The Regulatory Role of the Tetrapeptide AcSDKP in Skin and Hair Physiology and the Prevention of Aging Effects in These Tissues – A Potential Cosmetic Role

13 citations, March 2013 in “International Journal of Cosmetic Science”

AcSDKP may help prevent skin and hair aging and promote their growth.

research Lipid Nanoparticles for Topical and Transdermal Delivery of Pharmaceuticals and Cosmeceuticals

2 citations, January 2018 in “Elsevier eBooks”

Lipid nanoparticles improve drug delivery through the skin, offering stability, controlled release, and better compatibility with skin.

research IL-17 Axis Is a Significant Driver of Skin Inflammation in CARD14 Mutant Pityriasis Rubra Pilaris Model Mice

February 2023 in “Research Square (Research Square)”

Blocking IL-17 can reduce skin inflammation in a mouse model of pityriasis rubra pilaris.

research Metabolic and Pathologic Profiles of Human LSS Deficiency Recapitulated in Mice

23 citations, February 2020 in “PLOS genetics”

Mice with LSS deficiency showed hair loss and cataracts, similar to humans, and can help in understanding and treating this condition.

research A Folliculocentric Perspective of Dandruff Pathogenesis: Could a Troublesome Condition Be Caused by Changes to a Natural Secretory Mechanism?

3 citations, September 2021 in “BioEssays”

Dandruff might be caused by changes in how hair follicles naturally release oils and an immune response to this imbalance.