Erosive Pustular Dermatosis: A Manifestation of Immunosenescence - A Report of 8 Cases

November 2017 in “ Skin Appendage Disorders ”

Thusanth Thuraisingam, Paradi Mirmirani

erosive pustular dermatosis scarring alopecia chronic wounds immunosenescence epidermal barrier UV damage hormonal influences actinic damage EPD sun damage

TLDR Erosive pustular dermatosis in elderly people may be linked to aging immune systems and skin damage.

The study reported on 8 cases of Erosive Pustular Dermatosis (EPD) in elderly patients, averaging 84 years old, with histories of chronic sun damage and non-melanoma skin cancer. It suggested that immunosenescence, ultraviolet damage, and hormonal changes contributed to EPD. Treatments included high-potency topical corticosteroids, intralesional corticosteroids, topical tacrolimus, and antibiotics to address immune dysregulation and poor wound healing. The study emphasized understanding EPD's pathophysiology for better prevention, early recognition, and treatment. All subjects provided informed consent, and the study was ethically approved with no conflicts of interest disclosed.

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Research cited in this study

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