Erosive Pustular Dermatosis: A Manifestation of Immunosenescence - A Report of 8 Cases

    November 2017 in “ Skin Appendage Disorders
    Thusanth Thuraisingam, Paradi Mirmirani
    Studysummary This series of eight North American patients with erosive pustular dermatosis of the scalp suggests that factors like immunosenescence and ultraviolet damage may contribute to the condition's development.
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    The study reported on 8 cases of Erosive Pustular Dermatosis (EPD) in elderly patients, averaging 84 years old, with histories of chronic sun damage and non-melanoma skin cancer. It suggested that immunosenescence, ultraviolet damage, and hormonal changes contributed to EPD. Treatments included high-potency topical corticosteroids, intralesional corticosteroids, topical tacrolimus, and antibiotics to address immune dysregulation and poor wound healing. The study emphasized understanding EPD's pathophysiology for better prevention, early recognition, and treatment. All subjects provided informed consent, and the study was ethically approved with no conflicts of interest disclosed.
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