101 citations,
March 2019 in “Cell Stem Cell” Certain immune cells in the skin release a protein that stops hair growth by keeping hair stem cells inactive.
85 citations,
January 2018 in “Cell stem cell” Different signals work together to change gene activity and guide hair follicle stem cells to become specific cell types.
75 citations,
September 2016 in “EMBO journal” PRC2 is essential for maintaining intestinal cell balance and aiding regeneration after damage.
70 citations,
February 2016 in “EMBO reports” Scientists found a specific group of itch-sensing nerve cells in mice important for feeling itch but not for sensing heat or touch.
61 citations,
January 2011 in “PloS one” Notch signaling is essential for healthy skin and hair follicle maintenance.
60 citations,
July 2014 in “Autophagy” The protein FLCN is involved in cellular cleanup and is regulated by ULK1.
58 citations,
August 2015 in “The Indonesian Biomedical Journal” Different types of stem cells help maintain and heal skin.
44 citations,
July 2016 in “Stem Cells Translational Medicine” Scientists discovered that certain stem cells from mice and humans can be used to grow new hair follicles and skin glands when treated with a special mixture.
44 citations,
January 2015 in “Development” Human Schwann cells can be quickly made from hair follicle stem cells for nerve repair.
41 citations,
February 2021 in “Translational research” Non-coding RNAs could help detect and treat radiation damage.
38 citations,
September 2011 in “PLOS ONE” Activin B helps heal skin wounds and grow hair by activating a specific cell signaling pathway.
37 citations,
April 2018 in “Journal of Allergy and Clinical Immunology” A mutation in the IKZF1 gene causes immune system overactivity, linked to autoimmune diseases like lupus.
37 citations,
November 2017 in “Medical Sciences” Melanoma's complexity requires personalized treatments due to key genetic mutations and tumor-initiating cells.
33 citations,
May 2018 in “Stem Cell Reports” Krt15+ cells in the mouse intestine resist radiation and can start tumors.
33 citations,
March 2018 in “Trends in cell biology” Metabolism plays a key role in determining stem cell fate.
33 citations,
January 2018 in “Blood” Ruxolitinib helps protect skin stem cells and keeps skin healthy in mice with skin GVHD.
32 citations,
June 2021 in “Frontiers in Pharmacology” The hydrogel speeds up burn wound healing and promotes tissue regeneration.
32 citations,
December 2019 in “The Journal of clinical investigation/The journal of clinical investigation” A protein called IL-36γ causes skin side effects from certain cancer treatments when combined with a common skin bacteria.
25 citations,
June 2022 in “Developmental cell” Overactivating Hedgehog signaling makes hair follicle cells in mice grow hair faster and create more follicles.
25 citations,
June 2017 in “Neuropharmacology” Increasing TSPO in the brain reduces anxiety and depression.
23 citations,
July 2020 in “Aging Cell” Aging changes sugar molecules on skin stem cells, which may affect their ability to repair skin.
22 citations,
December 2015 in “The journal of investigative dermatology/Journal of investigative dermatology” A mouse gene mutation increases the risk of skin cancer.
22 citations,
July 2015 in “PloS one” Foxp1 helps control hair stem cell growth and response to stress during hair growth cycles.
21 citations,
January 2022 in “Biomaterials Science” RNA delivery is best for in-body use, while RNP delivery is good for outside-body use. Both methods are expected to greatly impact future treatments.
19 citations,
May 2022 in “International journal of molecular sciences” PRX01, PRX44, and PRX73 are essential for root hair growth in Arabidopsis thaliana.
16 citations,
July 2023 in “Acta biomaterialia” The study developed a new way to create hair-growing tissue that can help regenerate hair follicles and control hair growth direction.
16 citations,
March 2021 in “EvoDevo” Different species use the same genes for tooth regeneration.
15 citations,
January 2015 in “Stem cells international” Human hair follicle stem cells can be turned into red blood cells.
15 citations,
June 2019 in “eLife” Activin A and follistatin control when hair cells develop in mouse ears.
14 citations,
February 2022 in “The Journal of clinical investigation/The journal of clinical investigation” Scientists made a mouse model of a serious skin cancer by changing skin cells with a virus and a specific gene, which is similar to the disease in humans.