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Non-viral vectors show promise for safe and effective CRISPR/Cas9 gene editing in treating diseases.

In this mouse study, NF-κB was shown to play a role in hair follicle cycling and morphogenesis, with specific activity patterns differing by hair type and involving noncanonical signaling for zigzag hair bending.

This study found that topically delivering KGF-1 DNA plasmid increased epithelial thickness and skin strength, suggesting potential benefits for strengthening compromised skin.

This study found that in wound-induced hair neogenesis, African spiny mice and laboratory mice exhibit different morphogenetic field formation patterns related to tissue stiffness, suggesting evolutionary developmental biology advantages.

This study found that resveratrol and fisetin promoted hair growth in mice by inducing telomerase reverse transcriptase expression, which activates hair follicle stem cells and transitions follicles from a resting to a growth phase.

This study found that testosterone and dihydrotestosterone are crucial for synaptic transmission and spine density in male hippocampal neurons, suggesting sex-specific effects of neurosteroids on brain development.

This study found that certain keratin gene mutations associated with pachyonychia congenita are linked to altered enamel structure and increased risk of dental caries.

In this study, researchers identified a gene expression pre-pattern and implicated the Wnt inhibitor Dickkopf 4 in the formation of color patterns in domestic cat embryos.

This study found that deletion of c-Jun and JunB in mouse bulge hair follicle stem cells was sufficient to trigger psoriasis-like skin disease through thymic stromal lymphopoietin signaling.

This study found that melanocyte progenitor cells are present in human subcutaneous adipose tissue and may differentiate into mature melanocytes, suggesting potential applications in treating skin diseases and rejuvenation.

The researchers reported that minor salivary gland stem cells exhibit stem cell characteristics and respond to tobacco-derived carcinogens, implicating the transforming growth factor beta pathway in their maintenance.

This study introduces a new multimodal imaging technology to visualize and quantify cell dynamics in natural skin over long durations, demonstrated in GFP bone marrow-transplanted mice, to study dynamic skin regeneration.

This review summarizes that polyesters hold promise for vascular tissue engineering due to their mechanical properties and biodegradability, but optimizing their use in repairing damaged blood vessels remains challenging due to the complexity of vascular tissues.

The researchers found that HOXC13 regulates different keratin proteins in a mixed manner, with certain SNPs impeding this regulation, while also demonstrating negative-feedback by HOXC13 and positive regulation by LEF1 and melatonin on the HOXC13 promoter.

This study observed dynamic behaviors such as cluster formation, migration, and active proliferation of transplanted bone marrow cells in a mouse model, providing insight into cellular-level changes post-transplantation.

This study found that the postnatal thymus contains a population of mesenchymal stem cells that may help maintain functional thymic microenvironments.

This review provides guidance on using two-photon microscopy for real-time and long-term visualization of stem cell activity in live mice skin, focusing on its application in researching skin and stem cell biology.

This study developed a mouse model to monitor hair follicle cycling macroscopically through live bioluminescence imaging, enabling detailed analysis of hair cycle and propagation dynamics influenced by environmental factors.

This study identified a specific subpopulation of hair follicle stem cells in mice and humans that are essential for long-term hair regeneration, highlighting the potential for regenerative therapy.

This review article summarizes the potential role of advanced medical therapies—using genes, cells, and/or tissue engineering—in treating various types of alopecia, by examining clinical research, basic studies, and ongoing trials.

This study found that quiescent bulge stem cells, when prevented from contributing to hair follicle and epidermal regeneration, did not affect hair follicle growth or wound healing in the short term.

This study reports that transplanted mouse hair follicles restored piloerection ability and connected properly with host tissues, suggesting potential for advanced hair restoration therapies.

In this study using data from young women in West Bengal, India, the researchers identified that leptin signaling impairment, insulin resistance, and specific gene mutations significantly contribute to PCOS, with obesity commonly manifesting in affected individuals.

This review updates on the development of liposomal carriers for delivering growth factors to improve tissue regeneration and highlights recent efforts to enhance their stability and retention in tissues.

This study found that melatonin at 0.2 g/L for 72 hours most effectively enhances cashmere growth in Liaoning cashmere goats by upregulating the lncRNA MTC, which activates NF-kB signaling.

This study developed solid lipid nanoparticles for effective delivery of shRNA-encoding plasmids, showing reduced 5α-reductase levels in DU-145 cells without significant cytotoxicity.

In this review, researchers summarize the methods for characterizing telocytes, outline their physiological roles and implications in diseases, and discuss potential future studies including precise markers and targeted therapies.

In this study, Wnt4 was identified as a key factor in cardiac repair, where its regulation in cardiac fibroblasts improved cardiac function and revascularization following ischemic reperfusion injury.

This study demonstrated that adding human adipose-derived stem cells to hair follicle germ-like aggregates significantly improved hair shaft generation in transplanted nude mice, suggesting a promising strategy for hair regenerative medicine.

This study found that manipulating SIMK expression in alfalfa affects root hair growth, infection thread and nodule formation, and overall plant biomass, highlighting its potential biotechnological applications.