Role of Bulge Epidermal Stem Cells and TSLP Signaling in Psoriasis

    September 2019 in “ EMBO molecular medicine ”
    Nuria Gago-López, Liliana Mellor, Diego Megı́as … Erwin F. Wagner
    Studysummary This study found that deletion of c-Jun and JunB in mouse bulge hair follicle stem cells was sufficient to trigger psoriasis-like skin disease through thymic stromal lymphopoietin signaling.
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    Research cited in this study 11

    1. Stem Cell Plasticity Enables Hair Regeneration Following Lgr5+ Cell Loss Nature Cell Biology · 2017
    2. Gata6 Promotes Hair Follicle Progenitor Cell Renewal by Genome Maintenance During Proliferation The EMBO Journal · 2016
    3. Foxc1 Reinforces Quiescence in Self-Renewing Hair Follicle Stem Cells Science · 2016
    4. Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges BioEssays · 2014
    5. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    6. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    7. Nfatc1 Balances Quiescence and Proliferation of Skin Stem Cells Cell · 2008
    8. CD34 Expression by Hair Follicle Stem Cells Is Required for Skin Tumor Development in Mice Cancer Research · 2007
    9. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    10. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003
    11. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003