19 citations
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March 2013 in “Biology Letters” This study found that the main structural proteins of tree frog toe pads, which aid in their adhesive properties, are alpha keratins that have evolutionary origins in early tetrapods.
July 2024 in “Indian Dermatology Online Journal” In this case report, a benign trichoadenoma was identified in a 42-year-old man as a skin-colored nodule on the cheek, with histopathology confirming the diagnosis and differentiating it from similar conditions like pilomatricoma and sebaceous cyst.
1 citations
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September 2010 in “European Urology Supplements”
September 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that enteroendocrine cells play a key role in coordinating stem cell migration towards wounds in the Drosophila intestinal epithelium, aiding tissue repair through non-canonical Wnt signaling.
20 citations
,
September 2004 in “Journal of Anatomy” This study suggests that the structure and function of the inner root sheath in mammalian hair may have evolved from simpler forms seen in monotremes, aiding in hair exit without damaging the epidermis.
35 citations
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September 2006 in “American Journal Of Pathology” In this study, researchers found that overexpression of the Hedgehog signaling effector Gli2 in mice led to odontogenic keratocysts development, implicating GLI transcription factors in human keratocyst pathogenesis.
48 citations
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July 1993 in “Archives of Dermatological Research” Merkel cells are abundant in facial vellus hair follicles, especially during the anagen phase.
3 citations
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April 2019 in “Stem cells international” This study found that CRABP1, Nestin, and Ephrin B2 are expressed in both the tumor stroma and invasive front of skin adnexal tumors and basal cell carcinomas.
August 2016 in “KU ScholarWorks (The University of Kansas)” This study demonstrated that transplanting in vitro differentiated Wharton's jelly mesenchymal stem cells on acellular dermal grafts led to complete skin regeneration with appendages in a mouse model of full-thickness wounds.
39 citations
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February 2011 in “American Journal of Dermatopathology” This study shows for the first time that onychomatricoma can recapitulate the entire nail unit with differentiation toward the nail bed and isthmus, identifying new histopathological and immunohistochemical features.
82 citations
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February 2017 in “Cold Spring Harbor Perspectives in Biology” The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.
February 2017 in “Developmental Cell” This study reported that mammary stem cells in terminal end buds of the mammary gland primarily contribute to branching morphogenesis through dynamic positional regulation and cellular rearrangement.
6 citations
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January 2025 in “Differentiation” This review highlights the role of the glycoprotein WNT10A in human tissue and organ development, exploring its genetic structure, expression, and association with disorders like ectodermal dysplasia and pathological conditions such as fibrosis and cancer.
January 2006 in “Zhongguo bingli shengli zazhi” This study found that murine epidermal stem cells implanted subcutaneously in a biodegradable carrier could survive and differentiate into structures resembling native dermis without significant rejection in recipient mice.
This study found that upper-bulge epidermal stem cells in mouse hair follicles are specialized for nerve interactions, crucial for forming tactile sensory units, and influence touch responses via EGFL6 and αv integrin pathways.
April 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study identifies key transcriptomic features and a necessary dermal niche for eccrine gland development, advancing potential regenerative approaches for these vital skin appendages.
187 citations
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April 2019 in “npj Regenerative Medicine” This study found that hMSC secretomes from umbilical cord Wharton's jelly had the most potent angiogenic effects, whereas those from adipose tissue demonstrated the weakest angiogenic potential.
August 2015 in “PubMed Central” This study suggests that epithelial-derived Pop-Up Keratinocytes (ePUKs) may be a promising cell source for regenerative medicine due to their specific phenotypic traits and their influence on wound healing.
7 citations
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October 2018 in “BMC genomics” This study reveals that β-catenin and retinoic acid are key regulators in the gene networks controlling the fate of skin appendages, such as scales and feathers.
14 citations
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February 2020 in “Scientific reports” This study found that telocytes in human scalp tissue were located around hair follicles and glands and may be involved in skin regeneration and homeostasis.
29 citations
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February 1989 in “Journal of Cutaneous Pathology” This case report identifies a new type of hair matrix tumor called "rippled pattern trichomatricoma," distinguished by its unique cell arrangement and differentiation features.
24 citations
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September 2019 in “Experimental cell research” This study found that BMP2 increased PTEN expression and induced autophagy, promoting hair follicle stem cell differentiation in both in vitro models and a mouse wound model.
15 citations
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April 2011 in “Biological Chemistry” This study found that Cathepsin E plays a crucial role in keratinocyte terminal differentiation, affecting epidermis formation and homeostasis in mice.
16 citations
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March 2021 in “EvoDevo” This study found that zebrafish and sticklebacks, despite differences in their tooth regeneration structures, share a similar genetic program during tooth regeneration, suggesting a conserved "successional dental epithelium" in vertebrates.
October 2025 in “International Journal of Molecular Sciences” This study demonstrated that a novel hydrogel combining extracellular vesicles from chemically induced mammary epithelial cells with chitosan significantly enhanced skin wound healing in a rat model.
29 citations
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July 2003 in “Experimental Dermatology” This study found that in anagen hair follicles, the basement membrane zone components showed decreased expression in the lower hair bulb, with a complete absence of BP230 at the dermal papilla junction, suggesting an incomplete hemidesmosome structure in these regions.
59 citations
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March 1984 in “Journal of Investigative Dermatology”
22 citations
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December 2016 in “PloS one” In this study, researchers found that the EDMTFH protein is present in specific layers of the chicken embryo skin and feathers, suggesting its role in feather mechanics and development.
September 2023 in “Stem cell reviews and reports” This study introduces a new method to isolate stem cells from the hair follicle outer root sheath of equine skin, demonstrating that these cells, named eMSCORS, proliferate efficiently and can differentiate similarly to adipose tissue-derived MSCs, offering a promising alternative for equine veterinary applications.
May 2022 in “Research Square (Research Square)” This study found that nestin-expressing unipotent progenitor cells capable of differentiating into outer root sheath keratinocytes are present during hair follicle development and in adult hair follicles.