Non-Canonical Wnt Signaling Promotes Directed Migration of Intestinal Stem Cells to Sites of Injury

September 2021 in “ bioRxiv (Cold Spring Harbor Laboratory) ”

Daniel Jun-Kit Hu, Jina Yun, Justin Elstrott, Heinrich Jasper

non-canonical Wnt signaling intestinal stem cells tissue regeneration actin-based protrusions ISC proliferation PTK7 orthologue Otk enteroendocrine cells Drosophila intestinal epithelium

Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

Studysummary This study found that enteroendocrine cells play a key role in coordinating stem cell migration towards wounds in the Drosophila intestinal epithelium, aiding tissue repair through non-canonical Wnt signaling.

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research Stem Cell Dynamics, Migration, and Plasticity During Wound Healing

211 citations , November 2018 in “Nature Cell Biology”

This article discusses the coordinated roles of different epidermal stem cells and other cell types in the skin's wound healing process and reports no new experimental results.

research Defining Stem Cell Dynamics and Migration During Wound Healing in Mouse Skin Epidermis

363 citations , March 2017 in “Nature Communications”

This study found that, in mouse tail epidermis, stem cells rapidly activate and regenerate new progenitors to repair wounds, with mechanisms affecting their proliferation, differentiation, and migration.