TLDR Cathepsin E is crucial for normal skin cell differentiation and development.
The study explored the role of cathepsin E (CatE) in keratinocyte terminal differentiation. It was found that CatE deficiency in mice led to abnormal keratinocyte differentiation, characterized by expanded corium and reduced subcutaneous tissue and hair follicles. In skin papilloma models, CatE deficiency resulted in reduced expression and altered localization of differentiation proteins keratin 1 and loricrin. In vitro studies confirmed CatE's involvement in regulating epidermal differentiation proteins. Overexpression of CatE enhanced keratinocyte differentiation, while deficiency delayed it, suggesting CatE's crucial role in regulating epidermis formation and homeostasis.
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