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This article describes a protocol for using bioengineered techniques to regenerate functional hair follicles and their stem cell niches by manipulating epithelial and mesenchymal cells.

This article reviews the similarities in early development processes of hair follicles, teeth, and mammary glands and reports no new experimental findings.

This review discusses the strategies and progress in developing bioengineered organ replacement therapies but reports no new clinical results, highlighting the potential for future regenerative solutions.

Understanding skin structure and development helps diagnose and treat skin disorders.

This study found that back skin mesenchyme from mouse embryos can induce hair follicle formation even before dermal condensate formation, but R-spondin-1 alone or with a Bmp receptor inhibitor was not sufficient for hair follicle induction.

This review discusses potential cell sources and bioengineering strategies for regenerating hair follicles with functional cycling, reporting no new results.

This study found that epidermal Wnt production is crucial for forming the skin's spinous layer through a BMP-FGF signaling cascade, although Wnt from basal cells is not needed for their differentiation.

Researchers created a fully functional, bioengineered skin system with hair from stem cells that successfully integrated when transplanted into mice.

This study found that the transcription factors Msx2 and Foxn1 are crucial for maintaining Notch1 expression in the hair follicle matrix, which is necessary for proper hair differentiation.

This study demonstrated that bioengineered hair follicles reconstituted from embryonic skin cells and transplanted into hosts can restore physiological hair functions, suggesting potential applications for treating alopecia.

This review discusses recent advancements in regenerative medicine, including functional organ regeneration and the creation of mini-organs, and reports no new clinical results.

This study found that Wnt5a regulates hair follicle differentiation in mice by mediating epithelial-mesenchymal interactions and influencing dermal papilla cell activities.

Scientists turned rat thymus cells into stem cells that can help repair skin and hair.

In this study, mouse sweat gland development relied on a regulatory sequence initiated by Wnt/β-catenin signaling, and disruptions in Wnt, Eda, or Shh pathways led to distinct developmental failures.

In this study, researchers differentiated induced pluripotent stem cells into cells with dermal papilla-like properties, demonstrating their potential role in hair follicle bioengineering and drug testing for hair growth.

This study found that ILK deficiency disrupts hair follicle development by impairing cell polarity and laminin-511 assembly, but these defects can be partially reversed with exogenous laminin-511.

This study identified a specific subpopulation of hair follicle stem cells in mice and humans that are essential for long-term hair regeneration, highlighting the potential for regenerative therapy.

This chapter discusses the skin stem cell niche as a complex ecosystem and highlights the diverse components and interactions that influence stem cell function, but it reports no new experimental results.

This study used single-cell ATAC sequencing to map chromatin accessibility in developing mouse hair follicles, offering insights into the transcriptional regulation and epigenetic mechanisms underlying hair follicle development.

This review highlights the significance of animal fibers, examining the molecular mechanisms influencing hair follicle development and their impact on fiber quality and quantity, with a focus on studies involving Angora and cashmere goats.

This review discusses advancements in regenerative medicine for hair loss treatments, highlighting stem cell techniques for rejuvenating or creating hair follicles, but provides no new clinical results.

This review discusses the potential of exosomes and the secretome in stem cell-based regenerative therapies but reports no new experimental findings.

Activating the Eda/Edar pathway improves wound healing by enhancing hair follicle growth.

This review discusses recent advancements in hair follicle regeneration technologies, including the authors' own development of functional hair regeneration through bioengineered follicle germ transplantation, but reports no new clinical results.

In this review, the authors highlight the crucial role of mesenchymal stem cells in dermatologic therapies, noting their potential to enhance skin structure and appearance through regenerative mechanisms like inflammation induction, angiogenesis, and recruitment of tissue-specific progenitors.

This article reviews the complex signaling pathways between epithelial and mesenchymal cells crucial for hair follicle morphogenesis, highlighting the Wnt pathway's role as a master regulator without reporting new experimental findings.

This study demonstrates the potential of using bioengineered follicles from adult tissue-derived stem cells for fully functional hair regeneration, illustrating possible applications in organ replacement therapy.

This study found that overexpression of miR-214 in keratinocytes inhibits hair follicle development and cycling by targeting β-catenin in the Wnt signaling pathway.

This study found that a genetic variant in the EDAR gene leads to typical East Asian hair characteristics by increasing signaling output, as shown in transgenic mice experiments.

This study shows that BMP2 and BMP7 play complex, necessary roles in feather development by regulating dermal condensation formation, with BMP7 acting early as a chemoattractant and BMP2 halting cell migration.