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This study investigated improving Finasteride's water solubility using trimethyl-β-cyclodextrin (TM-β-CD) and β-cyclodextrin (β-CD) as carriers, finding that β-CD improved Fin's cumulative release, while TM-β-CD enhanced its solubility, with computational data supporting these outcomes.

Nanoparticles can improve drug delivery to hair follicles but struggle to penetrate deeper skin layers.

This review highlights recent advancements in nanotechnology-based approaches for treating androgenetic alopecia, focusing on enhancing drug delivery to hair follicles, controlled release, and follicular microenvironment modulation, while addressing safety, manufacturing, and regulatory challenges for clinical application.

This review highlights advancements in drug delivery systems for treating psoriasis and atopic dermatitis, focusing on their ability to enhance transdermal drug efficacy and safety by overcoming skin barriers and enabling precise, on-demand drug release at target sites.

This review article highlights recent advances in microneedle technology for wound healing and tissue regeneration, discussing various cargo types, structural designs, and fabrication methods, and suggesting guidelines for designing microneedle systems tailored to specific applications.

This study highlights the potential of polymeric micelles in enhancing the targeted delivery and efficacy of treatments for androgenetic alopecia, by offering improved retention on the scalp, extended release, and reduced systemic side effects compared to conventional therapies like minoxidil and finasteride.

This study found that FucoPol hydrogel membranes can effectively deliver model drugs such as caffeine and diclofenac sodium via different loading methods, with notable mechanical and release properties, suggesting their potential as platforms for topical drug delivery.

This review explores the potential of cell-mediated drug delivery systems in dermatology, highlighting their ability to target inflamed or diseased skin while discussing applications in diseases like atopic dermatitis and melanoma, along with challenges such as immunogenicity and manufacturing.

This study identified new genes and compounds affecting hair cell survival during ototoxin exposure using the zebrafish model, potentially aiding in understanding and preventing hearing loss and balance disorders in humans.

This review summarizes the current applications and mechanisms of self-assembled peptide hydrogels in promoting skin, bone, and nerve regeneration, highlighting their potential due to their biocompatibility and supportive role in tissue healing.

This article discusses the formulation of nanoemulsion systems as advanced drug delivery mechanisms, but it reports no new clinical findings.

This review summarizes recent progress in microneedle-based drug delivery systems and discusses their potential impact on cellular mechanisms and immunization signaling pathways, highlighting the need for further development in fabrication methods.

In this study, the researchers developed and optimized a bilayer tablet containing Tamsulosin and Finasteride, achieving sustained and immediate drug release with favorable release kinetics, including first-order and anomalous diffusion mechanisms, through in vitro testing.

In this review, researchers discussed recent advances in nanotechnology for topical skin applications, highlighting how nanocarriers enhance skin penetration and targeting in treatments for diseases like melanoma and psoriasis, while acknowledging that the penetration mechanisms and health impacts of nanoparticles remain not fully understood.

This review highlights that the combination of ultrasound and microneedles can enhance transdermal drug delivery by using physical and energy-driven mechanisms to improve drug penetration into deeper skin layers, with implications for precision medicine and chronic disease treatments.

This research highlights the potential of emulgel as an advanced topical drug delivery system, offering improved efficacy for hydrophobic medications in treating dermatological conditions and a range of ailments with its dual release control mechanism of gel and emulsion.

This review discusses the integration of biodegradable biomaterials with drugs and stem cells for diabetic wound repair, but reports no new clinical results and highlights the need for further translation to clinical practice.

This study found that finasteride ethosome formulations with specific ethanol and soya lecithin concentrations significantly enhanced transdermal drug delivery compared to a potential nanogel.

This review examines the use of microneedles for treating alopecia areata, highlighting their ability to enhance drug delivery through the skin by bypassing the outer barrier and promoting hair growth with minimal invasiveness.

This review found that microneedling can stimulate various biological pathways to promote tissue remodeling, enhance skin regeneration, and benefit conditions like wound healing and skin rejuvenation, with emerging uses in targeted drug delivery and periodontal therapy.

This research review outlines the challenges of diabetic wounds, such as diabetic foot ulcers, and examines the potential of electrospinning nanofiber scaffolds to improve healing by promoting tissue formation, allowing drug release, and enhancing specific wound healing properties.

This study aimed to enhance the skin penetration of minoxidil by encapsulating it in glycerosomal vesicles, offering a potential improvement in transdermal drug delivery for treating androgenetic alopecia. Results of the investigation were not reported.

This study examined the structural and biochemical mechanisms of human lipocalin prostaglandin D synthase, detailing substrate and product binding processes at the catalytic site and suggesting potential for drug delivery targeting hydrophobic molecules.

In this review, recent advances in long-acting microneedle-based transdermal drug delivery systems are outlined, highlighting biodegradable polymers like PLA, PLGA, and PCL for sustained release and discussing challenges in clinical translation such as consistency in manufacturing and validating long-term efficacy and safety.

This study describes a method to extract and characterize keratin particles from human hair, finding they can encapsulate the anticancer drug Paclitaxel with significant efficiency, releasing it in a pH-dependent manner potentially beneficial for targeted cancer treatment.

In this study, the release rate of Finasteride from Eudragit matrix tablets was found to be significantly influenced by the drug/Eudragit ratio and polymer viscosity, with formulation F9 being the most effective.

This article provides an overview of microneedle technology for transcutaneous drug delivery, discussing microneedle designs, materials, and activation methods that enhance drug stability and regulated release, and outlines considerations for their successful clinical implementation, such as biocompatibility and production cost.

This review discusses the mechanisms and storage of particles in hair follicles and presents no new experimental results, highlighting the need for further research in their safe application in dermatology and cosmetics.

This article proposes five mechanisms for telogen effluvium based on changes in the follicular cycle, which are supported by clinical findings, highlighting the condition's diverse causes.

This study found that exposing dermal papilla cells to sub-lethal doses of colchicine releases histone H4, which inhibits cell growth and decreases alkaline phosphatase activity, potentially explaining colchicine-induced hair loss.