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The enzyme RDH12 plays a role in vision and retinal disease, with mutations leading to early onset visual loss and blindness, but the exact disease mechanism is unclear and there are no treatments yet.

The study found that immune responses disrupt hair growth cycles, causing hair loss in alopecia areata.

The symposium highlighted the importance of understanding disease mechanisms for targeted dermatology treatments.

The C3H/HeJ mouse model is useful for studying and testing treatments for alopecia areata.

Keratin mutations cause skin diseases and could lead to new treatments.

Acne is significantly influenced by genetics, and understanding its genetic basis could lead to better, targeted treatments.

Zebrafish are useful for studying and developing treatments for human skin diseases.

Different people show different symptoms for genetic diseases because of how sensitive their bodies are to small changes in important factors.

Different types of cell death affect skin health and inflammation, and understanding them could improve treatments for skin diseases.

The symposium highlighted the importance of genetics in understanding and treating complex skin diseases.

Epigenetic factors play a crucial role in skin health and disease.

The study suggests that motor neurons created from stem cells of patients with spinal and bulbar muscular atrophy show signs of the disease, including changes in protein levels and cell functions.

The document concludes that while finding animal models for the skin disease Hidradenitis suppurativa is challenging, certain mouse mutations may provide useful insights for research and drug testing.

Alopecia areata involves both innate and adaptive immunity, with specific genes linked to the disease.

Scarring alopecias are complex hair loss disorders that require early treatment to prevent permanent hair loss.

Half of people with Alopecia Areata may see hair regrowth within a year without treatment, but recovery is unpredictable.

Current and future treatments for alopecia areata focus on immunosuppression, immunomodulation, and protecting hair follicles.

Catalytic antibodies are early indicators and active participants in the development of systemic lupus erythematosus.

Stress can cause a type of hair loss in mice lacking the CCHCR1 gene.

Certain mutations in the KLHL24 gene cause a skin disorder by breaking down an important skin protein.

Rare changes in the KRT82 gene are linked to a higher risk of Alopecia Areata.

Phosphorylation controls TFEB's location in the cell, affecting cell metabolism and stress response.

Epidermolysis bullosa simplex causes easily blistered skin due to faulty skin cell proteins, leading to new treatment ideas.

Cantú syndrome is caused by mutations in the ABCC9 gene.

The extracellular matrix is crucial for controlling skin stem cell behavior and health.

Genes play a significant role in male-pattern baldness, and understanding them could lead to new treatments and insights into related health issues.

Local skin glucocorticoid production is crucial for healthy skin, and its disruption can lead to skin diseases.

Effective treatments for spinal and bulbar muscular atrophy are not yet available; more research is needed.

Malondialdehyde-modified DNA may trigger an immune response in alopecia areata patients.

Alopecia areata is caused by immune system issues, and JAK inhibitors might help treat it.