Skin Organ Culture: Why?

April 1987 in “ International Journal of Dermatology ”

Raija Tammi, Howard I. Maïbach

skin organ culture dermatology skin tissues skin physiology skin pathology organ culture techniques skin biology disease mechanisms

Studysummary Skin organ culture helps us understand skin biology and diseases better.

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Research cited in this study

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research Basal Lamina Changes During Tissue Interactions in Hair Follicles: An In Vitro Study of Normal Dermal Papillae and Vitamin A-Induced Glandular Morphogenesis

34 citations , January 1983 in “Journal of Investigative Dermatology”

research Histochemical Evidence of Mucosubstances in the Metaplastic Epidermis and Hair Follicles Produced In Vitro in the Presence of Excess Vitamin A

20 citations , February 1977 in “The anatomical record”

This study found that excess vitamin A in organ cultures of mouse embryos led to significant changes in epidermis and hair follicles, altering morphogenesis and polysaccharide distribution.

research Effects of Steroid Hormones on Developing Mouse Skin In Vitro

6 citations , August 1975 in “Journal of Endocrinology”

This study found that cortisol and corticosterone led to thinning of the epidermis and hair follicle regression in fetal mouse skin, while testosterone promoted differentiation and sebaceous gland development.

research In Vitro Growth of Postembryonic Hair

38 citations , August 1973 in “Journal of Investigative Dermatology”

research Glandular Metaplasia of Hair Follicles and Other Responses to Vitamin A Excess in Cultures of Rodent Skin

77 citations , April 1968 in “Development”

This study found that excess vitamin A in organotypic cultures of embryonic mouse skin led to abnormal hair follicle development and glandular metaplasia, unlike in untreated controls that showed normal differentiation.