Acquired Immunogenicity of DNA After Modification with Malondialdehyde in Patients with Alopecia Areata

March 2014 in “ Scandinavian journal of clinical and laboratory investigation ”

Abdullateef A. Alzolibani, Zafar Rasheed, Ahmad A. Al Robaee

alopecia areata malondialdehyde MDA-DNA immunoglobulin G IgG autoimmune condition antibodies epitopes AA MDA

TLDR Malondialdehyde-modified DNA may trigger an immune response in alopecia areata patients.

The study investigated the role of malondialdehyde-modified DNA (MDA-DNA) in the autoimmune condition alopecia areata (AA). It was found that MDA caused significant DNA damage and that immunoglobulin G (IgG) from 45% of AA patients had a strong binding affinity to MDA-DNA compared to unmodified DNA, indicating that MDA-DNA could be highly immunogenic. Furthermore, when rabbits were induced to produce antibodies against MDA-DNA, these antibodies also showed binding to DNA isolated from AA patients. The results suggest that MDA modification of DNA may create new epitopes that could trigger antibody production in AA, providing insight into the immunological mechanisms of the disease.

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research Keratin 16 Expression Defines a Subset of Epithelial Cells During Skin Morphogenesis and the Hair Cycle

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research Failure of Passive Transfer of Serum From Patients With Alopecia Areata and Alopecia Universalis to Inhibit Hair Growth in Transplants of Human Scalp Skin Grafted Onto Nude Mice

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