Acquired Immunogenicity of DNA After Modification with Malondialdehyde in Patients with Alopecia Areata

March 2014 in “ Scandinavian journal of clinical and laboratory investigation ”

Abdullateef A. Alzolibani, Zafar Rasheed, Ahmad A. Al Robaee

alopecia areata malondialdehyde MDA-DNA immunoglobulin G IgG autoimmune condition antibodies epitopes AA MDA

TLDR Malondialdehyde-modified DNA may trigger an immune response in alopecia areata patients.

The study investigated the role of malondialdehyde-modified DNA (MDA-DNA) in the autoimmune condition alopecia areata (AA). It was found that MDA caused significant DNA damage and that immunoglobulin G (IgG) from 45% of AA patients had a strong binding affinity to MDA-DNA compared to unmodified DNA, indicating that MDA-DNA could be highly immunogenic. Furthermore, when rabbits were induced to produce antibodies against MDA-DNA, these antibodies also showed binding to DNA isolated from AA patients. The results suggest that MDA modification of DNA may create new epitopes that could trigger antibody production in AA, providing insight into the immunological mechanisms of the disease.

View this study on tandfonline.com →

Discuss this study in the Community →

Research cited in this study

8 / 8 results

research Alopecia Areata: An Update

67 citations, January 2013 in “Indian Journal of Dermatology, Venereology and Leprology”

The document concludes that alopecia areata is an autoimmune disease without a definitive cure, but treatments like corticosteroids are commonly used.

research Alopecia Areata Update

85 citations, October 2012 in “Dermatologic Clinics”

Alopecia Areata is an autoimmune condition often starting before age 20, with varied treatment success and a need for personalized treatment plans.

research Alopecia Areata as a Model for T Cell-Dependent Autoimmune Diseases

28 citations, May 2012 in “Experimental Dermatology”

research Alopecia Areata: An Autoimmune Disease Causing Hair Loss

421 citations, April 2012 in “The New England Journal of Medicine”

Alopecia Areata is an autoimmune condition causing hair loss with no cure and treatments that often don't work well.

research Increased Retinol-Binding Protein 4 and Anti-RBP4 Antibody in Alopecia Areata

6 citations, June 2011 in “British Journal of Dermatology”

People with alopecia areata have higher levels of RBP4 protein and antibodies against it.

research Etiopathogenesis of Alopecia Areata: Why Do Our Patients Get It?

53 citations, May 2011 in “Dermatologic therapy”

Alopecia areata is a skin condition causing hair loss, and its exact cause is unknown, but it may involve biological mechanisms.

research Autoimmunity: Alopecia Areata

143 citations, January 2004 in “Journal of Investigative Dermatology Symposium Proceedings”

Alopecia areata is an autoimmune disease causing hair loss, treatable with immune-modulating drugs, and linked to genetics.

research Antinuclear And Antithyroid Antibodies In 68 Japanese Patients With Alopecia Areata

6 citations, January 1999 in “Dermatology”

Alopecia areata is linked to autoimmune antibodies.

Similar Research

5 / 1000+ results

research Updates in the Pathogenesis of Alopecia Areata

April 2021 in “Sohag Medical Journal”

Alopecia areata is an autoimmune condition causing hair loss, linked to genetic factors and immune system issues, with no cure yet.

research Alopecia Areata: A Review of the Role of Oxidative Stress, Possible Biomarkers, and Potential Novel Therapeutic Approaches

15 citations, January 2023 in “Antioxidants”

Oxidative stress plays a significant role in alopecia areata, and new treatments may include JAK inhibitors and antioxidants.

Selenium and Systemic Lupus Erythematosus (SLE): A Double-Blind Randomized Controlled Trial

Acquired Immunogenicity of DNA After Modification with Malondialdehyde in Patients with Alopecia Areata

Research cited in this study

research Alopecia Areata: An Update

research Alopecia Areata Update

research Alopecia Areata as a Model for T Cell-Dependent Autoimmune Diseases

research Alopecia Areata: An Autoimmune Disease Causing Hair Loss

research Increased Retinol-Binding Protein 4 and Anti-RBP4 Antibody in Alopecia Areata

research Etiopathogenesis of Alopecia Areata: Why Do Our Patients Get It?

research Autoimmunity: Alopecia Areata

research Antinuclear And Antithyroid Antibodies In 68 Japanese Patients With Alopecia Areata

Related Community Posts Join

community Alopecia Areata Question

community mbp alopecia areata or vitamin deficiency

community Olumiant alternative for Alopecia Areata?

community Covid (likely) induced alopecia areata - now 2nd round of Covid, what can I expect?

community Onion Juice - An effective topical treatment for Alopecia Areata 🧬

community Nearly 40% of Adults with Alopecia Areata Taking OLUMIANT® 4-mg Saw at Least 80% Scalp Hair Coverage at 52 Weeks

Similar Research

research Updates in the Pathogenesis of Alopecia Areata

research Alopecia Areata: A Review of the Role of Oxidative Stress, Possible Biomarkers, and Potential Novel Therapeutic Approaches

research Selenium and Systemic Lupus Erythematosus (SLE): A Double-Blind Randomized Controlled Trial

research Association of Oxidative Stress in Mild Patchy Alopecia Areata: A Case-Control Study

research How Our Microbiome Influences the Pathogenesis of Alopecia Areata