Association of Oxidative Stress in Mild Patchy Alopecia Areata: A Case-Control Study

This study investigated the relationship between oxidative stress and mild patchy alopecia areata (AA) by comparing serum levels of total oxidant state (TOS), total antioxidant state (TAS), oxidative stress index (OSI), and ischemia-associated albumin (IMA) in 36 AA patients and 34 healthy volunteers. Results showed significantly higher TOS and OSI levels and significantly lower TAS levels in the AA group, indicating increased oxidative stress. Although IMA levels were higher in the AA group, the difference was not significant. The findings suggest that oxidative stress is associated with AA, and antioxidant defense mechanisms may be delayed in response to high oxidant levels. Further research is needed to explore individual oxidative causes and the effects of antioxidant treatment in larger and diverse AA populations.