Preferential Recognition of Hydroxyl Radical-Modified Superoxide Dismutase by Circulating Autoantibodies in Patients with Alopecia Areata

January 2014 in “ Annals of Dermatology ”

Abdullateef A. Alzolibani

alopecia areata hydroxyl radical superoxide dismutase autoantibodies neo-epitopes autoimmune response AA ·OH SOD

Studysummary This study found an association between hydroxyl radical-modified SOD and alopecia areata, suggesting these modifications may lead to antibody induction in the condition.

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research Oxidative Stress in Alopecia Areata: A Case-Control Study

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research Alopecia Areata: An Update

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This review discusses the causes, associated conditions, and treatment options for alopecia areata, such as corticosteroids and wigs, but reports no new clinical findings.

research Alopecia Areata Update

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This article reviews recent updates on alopecia areata, focusing on its causes, clinical presentation, and treatment options, and provides treatment plans by patient age and disease extent, but reports no new clinical results.

research Alopecia Areata as a Model for T Cell-Dependent Autoimmune Diseases

28 citations , May 2012 in “Experimental Dermatology”

This article discusses alopecia areata as a potential model for studying T cell-dependent autoimmune diseases and reports no new experimental findings.

research Treatment Strategies for Alopecia

34 citations , April 2009 in “Expert Opinion on Pharmacotherapy”

This review discusses evidence-based treatments for common hair loss forms, noting robust support for androgenetic alopecia therapies but limited long-term data and fewer high-quality studies for alopecia areata and cicatricial alopecias.

research Interventions for Alopecia Areata

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research Autoimmunity: Alopecia Areata

143 citations , January 2004 in “Journal of Investigative Dermatology Symposium Proceedings”

This review discusses the autoimmune nature of alopecia areata, potential therapeutic targets, and highlights the need for further studies on immunomodulatory treatments and genetic factors, but it reports no new clinical results.

research Antioxidants and Lipid Peroxidation Status in the Blood of Patients with Alopecia

55 citations , January 2000 in “Cell biochemistry and function”

This study observed that patients with alopecia had increased lipid peroxidation and decreased antioxidants, including lower beta-carotene, GSH levels, and GSH-Px activity, compared to healthy controls.