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GlossaryHydroxyl Radicals

highly reactive molecules damaging cells and DNA

Hydroxyl radicals (OH radicals) are highly reactive molecules that contain one oxygen and one hydrogen atom. They are often formed during the breakdown of water molecules by ultraviolet light or through certain chemical reactions. In biological systems, hydroxyl radicals can cause significant damage to cells, proteins, and DNA, contributing to aging and various diseases, including those affecting hair health and potentially leading to conditions like alopecia.

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research Hydroxyl Radical Mediates Cisplatin-Induced Apoptosis in Human Hair Follicle Dermal Papilla Cells and Keratinocytes Through Bcl-2-Dependent Mechanism

52 citations , May 2011 in “APOPTOSIS”

Hydroxyl radicals cause hair follicle cell death during chemotherapy by reducing Bcl-2 protein levels.

research Preferential Recognition of Hydroxyl Radical-Modified Superoxide Dismutase by Circulating Autoantibodies in Patients with Alopecia Areata

12 citations , January 2014 in “Annals of Dermatology”

Modified superoxide dismutase may trigger an autoimmune response in alopecia areata.

research Phenolic Compound Content, Antioxidant and Radical-Scavenging Properties of Methanolic Extracts from the Seed Coat of Certain Thai Tamarind Cultivars

10 citations , March 2010 in “Journal of Food Biochemistry”

Tamarind seed coats have strong antioxidant properties and could be used in health products and food preservatives.

research Hair Coloring Systems Delivering Color With Reduced Fiber Damage

1 citations , September 2008 in “International Journal of Cosmetic Science”

Using chelants in hair dye reduces fiber damage by preventing harmful radicals.

research Ultrasonic-Assisted Extraction and In-Vitro Antioxidant Activity of Polysaccharide from Hibiscus Leaf

59 citations , August 2014 in “International Journal of Biological Macromolecules”

The study found an efficient method to extract antioxidants from Hibiscus leaves.

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community Looking to make my own 2-Deoxy-D-ribose. Any science bros can give advice?

in Research/Science 7 upvotes 1 year ago

A user is making a 2-Deoxy-D-ribose solution and asks if it can be put into an oil instead of a gel, considering adding hydrocortisone and retinoic acid. They seek advice on the best carrier oil for hair growth.

community Yes your lifestyle and diet has its role in hair loss.

in Chat 296 upvotes 3 months ago

Diet and lifestyle changes can reduce hair shedding but won't regrow hair lost to genetic male pattern baldness. Treatments like finasteride and dutasteride are necessary for significant hair regrowth.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 96 upvotes 5 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community Interpreting pre-finisteride blood panels

in Chat 2 upvotes 6 months ago

The conversation is about someone planning to start finasteride for hair loss and wanting to interpret pre-treatment blood panels to assess the risk of side effects like gynecomastia. They list various tests to measure hormone levels and other health indicators.

community Pre-Finisteride DHT & Hormone Blood Panel

in Finasteride/Dutasteride 3 upvotes 6 months ago

The conversation discusses the cost and insurance coverage of a comprehensive hormone and DHT blood panel for hair loss, with a focus on finasteride treatment. The user seeks a cheaper alternative to a $700 panel recommended in a video.

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