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A missing mK6irs1 gene causes hair loss in mice.

In this study, knockout mice lacking the Cyp4f39 gene showed severe skin barrier dysfunction and high early mortality, suggesting its critical role in skin barrier formation and insights into ichthyosis pathogenesis.

This study found that disrupting Lm332 expression in mice changes keratinocyte genetic expression, alters cell shape, and disrupts epidermal homeostasis, despite some compensatory anchorage by hair follicle basal cells.

This study found that treating reconstructed human epidermis with beta-lipohydroxy salicylic acid increased tight junction remnants in the stratum corneum, potentially affecting skin cohesion and desquamation.

This study reviews iron metabolism in the skin, highlighting how differentially expressed genes regulate iron recycling in the epidermis, and discusses changes in iron metabolism related to skin diseases.

This study demonstrated that keratin K124 is specific to equine hoof lamellar tissue and established monoclonal antibodies that can specifically recognize K124 without cross-reacting with other tissues.

This study mapped gene expression in different skin structures of dogs, finding similarities to humans that support using dogs as models for human skin diseases.

A gene mutation in mice causes increased mast cells and disorganized hair follicles in their skin.

This study reports that vitamin A deficiency can cause dermatologic issues like alopecia and orthokeratosis in Angus calves, and affected calves improved with vitamin A supplementation.

This review discusses the role of zinc and its transporters in skin health and disorders, providing an overview without presenting new clinical results.

This study provides insights into how chronic T. gondii infection might affect testicular tissue and suggests a potential impact on male fertility.

In this study, researchers identified 47 proteins associated with male pattern baldness severity and prioritized five candidate genes, including druggable CD38, suggesting new non-hormonal targets for therapeutic development.

This study integrated single-cell RNA-seq data from four previous studies to create a comprehensive human corneal cell state meta-atlas, revealing novel marker genes, rare cell states, and distinct transcription factors, and offering a tool to enhance future cornea research.

This study found that human meibomian glands differ significantly from free and hair-associated sebaceous glands in morphology and lipid composition, making them highly specialized holocrine glands.

This review explores the cellular mechanisms of tissue repair and discusses how advancements in understanding wound pathology could lead to the development of more effective therapies for chronic, non-healing wounds, which are prevalent among individuals with diabetes and aging.

This article reviews the cellular and molecular processes of acute and chronic wound healing, emphasizing the need for collaboration between researchers and clinicians to advance therapeutic solutions; it presents no new clinical results.

This review examines the process of cornification as a mode of programmed cell death and outlines how keratinocytes activate anti-cell death mechanisms to maintain epidermal homeostasis, but reports no new results.

This study observed that vitamin D receptor knockout mice exhibit impaired epidermal differentiation and progressive hair loss, suggesting the importance of the vitamin D receptor in normal skin and hair follicle development.

This review discusses the regulation of involucrin gene expression, focusing on transcription factors and signaling pathways, and reports no new experimental findings.

This study found that COL17 deficiency in neonatal mice causes abnormal skin cell proliferation due to disrupted Wnt signaling, while replenishing or overexpressing COL17 can reverse this effect in both neonatal and aged skin.

A mutation in the KRT74 gene causes tightly curled hair.

This study found that disrupting the Sox21 gene in mice led to progressive hair loss and regrowth, identifying Sox21 as a key regulator of hair shaft cuticle differentiation.

This study suggests a regulatory model where HOXC13 activates Foxn1, affecting hair and nail differentiation, supported by similarities in Hoxc13(tm1Mrc) and Foxn1(nu) mice phenotypes and gene expression patterns.

This study introduces a method for long-term expansion of adult mouse epidermal stem cells in vitro using an organoid culture system that maintains the basal-apical organization.

This study found that autophagy is impaired in Birt-Hogg-Dubé syndrome-associated renal tumors and identified that the FLCN protein interacts with key autophagy components regulated by ULK1.

This publication provides a standardized nomenclature for classifying microscopic lesions in laboratory rat and mouse skin, aiming to harmonize international toxicological research.

This study found that stage-specific epigenetic changes, particularly involving the gene PDGFC, may affect wool fiber development in Zhongwei goats, potentially serving as a biomarker for fur goat selection.

This systematic review investigated colchicine as a potential treatment for various skin conditions, finding that most studies reported generally positive clinical outcomes when used alone or with other drugs, despite some variability in results.