31 citations
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February 2007 in “Journal of Structural Biology” Oxidation changes the structure of hair protein filaments, causing them to compact and rearrange.
February 2022 in “Fibers” This study found that a sucrose-based crosslinker can effectively straighten hair and maintain durability in high humidity and through repeated washings without affecting the hair's tensile properties or causing surface damage.
5 citations
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September 2023 in “International Journal of Molecular Sciences” This study found that FucoPol hydrogel membranes can effectively deliver model drugs such as caffeine and diclofenac sodium via different loading methods, with notable mechanical and release properties, suggesting their potential as platforms for topical drug delivery.
2 citations
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January 1968 in “PubMed” This study found that X-irradiation causes hair dysplasia through two mechanisms influenced by oxygen, and cystamine injections after irradiation enhance this effect.
This case report describes a novel mutation in the CDH3 gene in an 11-year-old Iranian boy with sparse scalp hair and macular dystrophy, leading to altered P-cadherin synthesis.
This study introduced Cadd4, a peptide-based degrader developed using computer-aided drug design, which effectively reduced PCSK9 levels and increased LDL receptor expression, resulting in decreased plasma cholesterol and LDL-C levels in hypercholesterolemic mice, without liver toxicity.
135 citations
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October 1997 in “Journal of biological chemistry/The Journal of biological chemistry” This study suggests that trichohyalin is modified by peptidyl-arginine deiminase before being cross-linked by TGase 3, allowing the formation of rigid structures in hair follicle cells.
1 citations
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May 2025 in “Carbohydrate Polymers” The new chitosan dressing heals wounds better and faster than current products.
46 citations
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June 2013 in “Journal of structural biology” This study suggests that the mechanical robustness of hair may be enhanced by the binding interactions of keratin-associated proteins, particularly KAP8.1, with intermediate filament proteins.
25 citations
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January 2024 in “Journal of Lipids” This review reports that cubosomes, used as drug nanocarriers in topical treatments, offer potential benefits for managing skin and eye diseases by improving bioadhesion, retention, and sustained release compared to conventional formulations, but also face manufacturing and biological challenges for effective clinical outcomes.
33 citations
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August 2000 in “Experimental Cell Research” 30 citations
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February 2023 in “Biomaterials Research” This study evaluated a new carboxymethyl chitosan/polyaldehyde dextran (CMCS/PD) hydrogel and found it to be a promising tissue adhesive for trauma emergencies in rats, showing rapid gel formation, strong adhesion, and better antibacterial properties than some commercial alternatives.
January 2022 in “Chemistry: A European Journal” This study found that synchrotron radiation ECD imaging provides new insights into solid-state Finasteride by highlighting the significant role of anisotropy in local domains for chiroptical measurements.
In this study, a novel CT@GA-gel hybrid hydrogel was developed for diabetic wound treatment, demonstrating improved mechanical properties, tissue adhesion, and chronic wound healing benefits, including immune regulation and re-epithelialization, due to enhanced crosslinking and ROS scavenging by incorporated carbon dots.
75 citations
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September 2015 in “Acta biomaterialia” This study found that alkylation of kerateine cysteine residues created a cell-compatible method for controlling hydrogel erosion rates and therapeutic agent release in keratin-based systems.
10 citations
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November 2013 in “Biochemistry and Molecular Biology Education” This review discusses the history, structure, and biological significance of keratins, including the crystal structure of a keratin helical segment, without reporting new experimental results.
November 2025 in “Advanced Healthcare Materials” This study found that incorporating CTA2-BADG, a modified hair-rebonding compound, into damaged hair significantly improved surface morphology and tensile strength by using charge-conversion chemistry to enhance penetration into the hair shaft.
3 citations
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January 2004 in “Sen i Gakkaishi” This study found that adding dithiodiglycolic acid to the hair straightening process decreased chemical damage and preserved the structural integrity of the hair matrix compared to using thioglycolic acid alone.
April 2018 in “Journal of Investigative Dermatology” In this study, researchers identified CENPV as a new CYLD interacting partner that localizes to primary cilia and regulates acetylated tubulin levels, offering insights into the pathogenesis of skin appendage tumors.
97 citations
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March 2002 in “Molecular and cellular biology” This study found that mice with a mutant CDP/Cux protein lacking the homeodomain showed severely impaired growth, high postnatal mortality, and reduced fertility, highlighting CDP/Cux's role in developmental regulation.
9 citations
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April 2019 in “Journal of structural biology” This study found that coconut oil impedes hair hydration more effectively than soybean oil by penetrating deeper, and suggested a new model for intermediate filament assembly in hair.
15 citations
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February 2023 in “Colloids and surfaces. B, Biointerfaces” In this study using a porcine skin model, the researchers reported that smaller curcumin nanocrystals in xanthan gum gel showed higher passive skin penetration, while larger particles achieved deeper follicular accumulation.
7 citations
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June 2019 in “Coloration Technology” This research found that translucent keratin films absorbed more dye than opaque films, suggesting they may serve as better screening substrates for evaluating hair dye effectiveness.
April 2019 in “Journal of Investigative Dermatology” This study demonstrated that gene-corrected 3D skin constructs from RDEB patient-derived iPSCs, grafted onto immunocompetent mice, showed normal collagen VII expression after two months.
4 citations
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November 2024 in “International Journal of Biological Macromolecules” In this study, the researchers developed a cellulose nanofiber-based scaffold containing sitagliptin and zinc sulfide nanoparticles, which promoted scarless healing and hair follicle regeneration in rats by targeting DPP4+ fibroblasts, suggesting a novel approach for improved wound healing and skin regeneration.
47 citations
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April 2017 in “European Journal of Pharmaceutics and Biopharmaceutics” This study found that dutasteride-loaded nanostructured lipid carriers coated with a stearic acid-chitosan oligomer are stable, less cytotoxic, and suitable for topical delivery to promote hair growth.
This study found that encapsulating ascorbyl palmitate in curcumin-grafted nanoparticles increased its stability compared to unencapsulated forms, with primary skin penetration occurring through hair follicles in pig skin.
20 citations
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March 2013 in “Journal of Lipid Research” This study examined the structural and biochemical mechanisms of human lipocalin prostaglandin D synthase, detailing substrate and product binding processes at the catalytic site and suggesting potential for drug delivery targeting hydrophobic molecules.
23 citations
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October 2021 in “AAPS PharmSciTech”