Negatively Charged Carbon Dot-Linked Glycyrrhizic Acid Hydrogel Promoted Hemostasis, Immunoregulation, and Re-Epithelialization of Wound Closure

The study presents an innovative hydrogel, CT@GA-gel, which combines glycyrrhizic acid with negatively charged carbon dots derived from charred Trachycarpus. This hydrogel is designed for the treatment of chronic wounds, particularly diabetic wounds. The addition of carbon dots allows the hydrogel to form at low concentrations, enhancing its mechanical properties and tissue adhesion, which promotes rapid hemostasis. The hydrogel also exhibits reactive oxygen species scavenging activity, aiding in immune regulation, re-epithelialization, and hair follicle growth, thus facilitating wound closure. Transcriptomics analysis showed increased gene expression related to hemostasis, cell adhesion, and extracellular matrix deposition, indicating improved wound repair. This research offers promising advancements in regenerative medicine for chronic tissue injuries.