TLDR Zinc sulfide cellulose scaffolds can reduce scarring and promote hair growth.
The study investigates the use of cellulose nanofiber scaffolds with sitagliptin and zinc sulfide nanoparticles to achieve scarless wound healing and hair follicle regeneration by targeting Dipeptidyl Peptidase 4 positive fibroblasts. The scaffold reduces fibrosis, improves collagen ratios, and enhances hair follicle generation. In vivo experiments on rats showed reduced skin fibrosis and increased new hair follicles, while in vitro studies indicated that the scaffold inhibits extracellular matrix secretion and fibroblast-to-myofibroblast conversion, promoting scarless healing. This approach could be a promising therapy for reducing scarring and enhancing skin regeneration.
September 2023 in “Nature Communications” Immune cells are essential for skin regeneration using biomaterial scaffolds.
66 citations
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May 2021 in “Science Advances” Different scaffold patterns improve wound healing and immune response in mouse skin, with aligned patterns being particularly effective.
305 citations
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March 2018 in “International journal of molecular sciences” The document concludes that the understanding of scar formation is incomplete and current prevention and treatment for hypertrophic scars and keloids are not fully effective.
21 citations
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November 2015 in “Phytomedicine” Glycyrrhizic acid may help reduce unwanted hair growth.
359 citations
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January 2015 in “Cold Spring Harbor Perspectives in Medicine” Hair growth phase and certain genes can speed up wound healing, while an inflammatory mediator can slow down new hair growth after a wound. Understanding these factors can improve tissue regeneration during wound healing.
1235 citations
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December 2013 in “Nature” Two fibroblast types shape skin structure and repair differently.
July 2025 in “Bioactive Materials” New engineering methods show promise for regenerating hair follicles using stem cells and advanced technologies.
16 citations
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September 2018 in “Journal of Ethnopharmacology” Plant-based remedies may treat hair loss by reducing inflammation and improving insulin resistance.
1 citations
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November 2011 in “British journal of pharmacology” Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.
132 citations
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June 2016 in “Cell and Tissue Research” The right cells and signals can potentially lead to scarless wound healing, with a mix of natural and external wound healing controllers possibly being the best way to achieve this.
January 2019 in “Advances in stem cells and their niches” Skin health and repair depend on the signals between skin stem cells and their surrounding cells.
