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GlossaryDipeptidyl Peptidase-4 (DPP-4)

enzyme that breaks down incretin hormones, regulating insulin levels

Dipeptidyl Peptidase-4 (DPP-4) is an enzyme that plays a role in glucose metabolism by breaking down incretin hormones, which help regulate insulin levels in the body. It is also known as CD26 and is involved in immune system functions. Inhibitors of DPP-4 are used in the treatment of type 2 diabetes to improve blood sugar control.

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research Basic Mechanisms of SARS-CoV-2 Infection: Implications for Endocrine Systems

14 citations , July 2021 in “Reviews in endocrine and metabolic disorders”

SARS-CoV-2, the virus causing COVID-19, can affect all endocrine organs and systems, altering their function and potentially leading to disorders. Factors like diabetes and obesity increase infection risk and severity. Understanding these effects is key for effective treatment.

research A Peptide Derivative with Known Anti-Wrinkle Properties Identified as Potent Dipeptidylpeptidase-4 Inhibitor

April 2016 in “Journal of Investigative Dermatology”

A peptide known for reducing wrinkles also effectively inhibits an enzyme linked to skin inflammation and acne.

research Inhibiting Dipeptidyl Peptidase 4 Positive Fibroblasts Using Zinc Sulfide Cellulose Nanofiber Scaffolds to Achieve Scarless Healing

4 citations , November 2024 in “International Journal of Biological Macromolecules”

Zinc sulfide cellulose scaffolds can reduce scarring and promote hair growth.

research Linagliptin-Associated Alopecia and Bullous Pemphigoid

7 citations , September 2019 in “European Journal of Case Reports in Internal Medicine”

Linagliptin may cause hair loss and skin blisters.

research Cardiovascular Profile of Pharmacological Agents Used for the Management of Polycystic Ovary Syndrome

4 citations , January 2019 in “Therapeutic Advances in Endocrinology and Metabolism”

Medications for PCOS don't seem to raise heart disease risk.

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