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Did you mean Cyclin-dependent kinase inhibitors?

GlossaryCDK inhibitors (Cyclin-dependent kinase inhibitors)

block enzymes that regulate cell cycle progression

CDK inhibitors, or Cyclin-dependent kinase inhibitors, are a class of drugs that block the activity of enzymes known as cyclin-dependent kinases (CDKs). These enzymes play a crucial role in regulating the cell cycle, and their inhibition can halt the proliferation of cancer cells, making CDK inhibitors valuable in cancer treatment.

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Fatigue, Alopecia, and Stomatitis Among Patients With Breast Cancer Receiving Cyclin-Dependent Kinase 4 and 6 Inhibitors: A Systematic Review and Meta-Analysis

research Fatigue, Alopecia, and Stomatitis Among Patients With Breast Cancer Receiving Cyclin-Dependent Kinase 4 and 6 Inhibitors: A Systematic Review and Meta-Analysis

28 citations, July 2017 in “Expert Review of Anticancer Therapy”

Breast cancer patients taking CDK4/6 inhibitors are more likely to experience fatigue, hair loss, and mouth sores.

Cyclin-Dependent Kinase 4/6 Inhibitors and Dermatologic Adverse Events: Results from the EADV Task Force Dermatology for Cancer Patients International Study

research Cyclin-Dependent Kinase 4/6 Inhibitors and Dermatologic Adverse Events: Results from the EADV Task Force Dermatology for Cancer Patients International Study

1 citations, July 2023 in “Cancers”

Skin side effects from CDK4/6 inhibitors in breast cancer patients are generally mild and treatable, allowing most patients to continue treatment.

research Factors Regulating Quiescent Stem Cells: Insights from the Intestine and Other Self-Renewing Tissues

8 citations, December 2015 in “The Journal of Physiology”

The document concludes that stem cell inactivity is actively controlled and important for tissue repair and balance.

P21Waf1/Cip1 Is Differentially Expressed in Epidermal Versus Follicular Melanocytes and Melanoma Cells and Is Phenotypically Regulated by UVB-Mediated Apoptosis

research P21Waf1/Cip1 Is Differentially Expressed in Epidermal Versus Follicular Melanocytes and Melanoma Cells and Is Phenotypically Regulated by UVB-Mediated Apoptosis

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

The protein p21 is more abundant in normal skin cells than in melanoma cells and may help protect against melanoma, with UVB light affecting its levels.

ATP-Competitive mTOR Kinase Inhibitors Delay Plant Growth by Triggering Early Differentiation of Meristematic Cells Without Developmental Patterning Change

research ATP-Competitive mTOR Kinase Inhibitors Delay Plant Growth by Triggering Early Differentiation of Meristematic Cells Without Developmental Patterning Change

161 citations, August 2013 in “Journal of experimental botany”

Certain inhibitors slow down plant growth by causing early cell specialization without changing the cell development pattern.

research Annotated Patent Selections

January 2000 in “Expert Opinion on Therapeutic Patents”

The document highlights various patents for new compounds with potential treatments for multiple diseases, including cancer, hormonal disorders, and diabetes.

research Nuclear Factor I-C Regulates TGF-β-dependent Hair Follicle Cycling

25 citations, August 2010 in “Journal of Biological Chemistry”

Nuclear Factor I-C is important for controlling hair growth by affecting the TGF-β1 pathway.

research Managing Hyperglycemia and Rash Associated With Alpelisib: Expert Consensus Recommendations Using the Delphi Technique

1 citations, January 2024 in “NPJ breast cancer”

Experts agree on how to manage sugar levels and skin reactions in patients taking the cancer drug alpelisib.

research Reversing Gray Hair: Inspiring the Development of New Therapies Through Research on Hair Pigmentation and Repigmentation Progress

2 citations, January 2023 in “International journal of biological sciences”

Gray hair can potentially be reversed, leading to new treatments.

research An ERK-Dependent Molecular Switch Antagonizes Fibrosis and Promotes Regeneration in Spiny Mice

1 citations, April 2023 in “Science Advances”

High levels of ERK activity are key for tissue regeneration in spiny mice, and activating ERK can potentially redirect scar-forming healing towards regenerative healing in mammals.

12-O-Tetradecanoylphorbol-13-Acetate Induces Apoptosis in Renal Epithelial Cells Through a Growth Signal Conflict Prevented by Activated Ras

research 12-O-Tetradecanoylphorbol-13-Acetate Induces Apoptosis in Renal Epithelial Cells Through a Growth Signal Conflict Prevented by Activated Ras

4 citations, January 2001 in “Archives of Biochemistry and Biophysics”

Activated ras can protect kidney cells from a certain substance that causes cell death.

research Linking Diet to Acne Metabolomics, Inflammation, and Comedogenesis: An Update

138 citations, July 2015 in “Clinical, Cosmetic and Investigational Dermatology”

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

research The JAK/STAT Signaling Pathway: From Bench to Clinic

489 citations, November 2021 in “Signal Transduction and Targeted Therapy”

The JAK/STAT pathway is important in cell processes and disease, and JAK inhibitors are promising for treating related conditions.

Hair Growth Stimulation Effect of Centipeda Minima Extract: Identification of Active Compounds and Anagen-Activating Signaling Pathways

research Hair Growth Stimulation Effect of Centipeda Minima Extract: Identification of Active Compounds and Anagen-Activating Signaling Pathways

14 citations, July 2021 in “Biomolecules”

Centipeda minima extract helps hair grow by activating important growth signals and could be a promising hair loss treatment.

research Proteasome Inhibitors: An Expanding Army Attacking a Unique Target

474 citations, January 2012 in “Chemistry & biology”

Proteasome inhibitors are promising treatments for various cancers, autoimmune diseases, and other conditions.

research Prevention of Chemotherapy-Induced Alopecia in Rats by CDK Inhibitors

153 citations, January 2001 in “Science”

Using CDK inhibitors on rats showed a reduction in chemotherapy-caused hair loss, but later experiments could not repeat these results.

research Predictive Modeling of Patient Response to JAK/STAT Inhibitors and Dynamic Patient-Matching

April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

Machine learning can predict how well patients with alopecia areata will respond to certain treatments.

research Promotion of Hair Growth in Alopecia Areata by Topical Treatment of HDAC Inhibitors

April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

HDAC inhibitors, like Vorinostat and Entinostat, can help regrow hair in alopecia areata.

PBX Homeobox 1 Enhances Hair Follicle Mesenchymal Stem Cell Proliferation and Reprogramming Through Activation of the AKT/Glycogen Synthase Kinase Signaling Pathway and Suppression of Apoptosis

research PBX Homeobox 1 Enhances Hair Follicle Mesenchymal Stem Cell Proliferation and Reprogramming Through Activation of the AKT/Glycogen Synthase Kinase Signaling Pathway and Suppression of Apoptosis

26 citations, August 2019 in “Stem Cell Research & Therapy”

PBX1 helps hair stem cells grow and change by turning on certain cell signals and preventing cell death, which may be useful for hair regrowth treatments.

Progesterone-Induced Stimulation of Mammary Tumorigenesis Is Due to the Progesterone Metabolite, 5α-Dihydroprogesterone (5αP), and Can Be Suppressed by the 5α-Reductase Inhibitor, Finasteride

research Progesterone-Induced Stimulation of Mammary Tumorigenesis Is Due to the Progesterone Metabolite, 5α-Dihydroprogesterone (5αP), and Can Be Suppressed by the 5α-Reductase Inhibitor, Finasteride

21 citations, May 2015 in “The Journal of Steroid Biochemistry and Molecular Biology”

Progesterone byproduct 5αP stimulates mammary tumor growth, but finasteride can suppress it.

research Treatment of Cultured Sebocytes with an EGFR Inhibitor Does Not Lead to Significant Upregulation of Inflammatory Biomarkers

3 citations, January 2011 in “Annals of Dermatology”

Blocking EGFR in skin cells doesn't majorly increase inflammation markers.

research HDAC6-Dependent Deacetylation of NGF Dictates Its Ubiquitination and Maintains Primordial Follicle Dormancy

January 2024 in “Theranostics”

HDAC6 helps keep ovarian follicles dormant, extending female fertility.

Cyclosporin A-Induced Hair Growth in Mice Is Associated with Inhibition of Calcineurin-Dependent Activation of NFAT in Follicular Keratinocytes

research Cyclosporin A-Induced Hair Growth in Mice Is Associated with Inhibition of Calcineurin-Dependent Activation of NFAT in Follicular Keratinocytes

57 citations, June 2003 in “American Journal of Physiology-cell Physiology”

Cyclosporin A helps mice grow hair by blocking a specific protein activity in skin cells.

Transient Mitochondrial DNA Double Strand Breaks in Mice Cause Accelerated Aging Phenotypes in a ROS-Dependent but p53/p21-Independent Manner

research Transient Mitochondrial DNA Double Strand Breaks in Mice Cause Accelerated Aging Phenotypes in a ROS-Dependent but p53/p21-Independent Manner

42 citations, December 2016 in “Cell Death & Differentiation”

Damaging mitochondrial DNA in mice speeds up aging due to increased reactive oxygen species, not through the p53/p21 pathway.

research Molecular Regulation of Melanocyte Senescence

85 citations, July 2002 in “Pigment Cell Research”

The article concludes that while we understand a lot about how melanocytes age and how this can prevent cancer, there are still unanswered questions about certain pathways and genes involved.