research Advances in skin grafting and treatment of cutaneous wounds
This review discusses current and experimental treatments for cutaneous wounds, emphasizing cell-based therapies and skin transplantation, but reports no new clinical results.
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research Cutaneous wound healing: recruiting developmental pathways for regeneration
This review discusses the roles of key developmental signaling pathways in mammalian skin repair compared to skin development, and suggests these insights could lead to better wound healing therapies, but it reports no new findings.
research Advances of Stem Cell Therapeutics in Cutaneous Wound Healing and Regeneration
This review examines current treatments and the potential role of stem cells in cutaneous wound healing, but it presents no new clinical results and calls for more research on mechanisms.
research An Extended Epidermal Response Heals Cutaneous Wounds in the Absence of a Hair Follicle Stem Cell Contribution
This study found that in the absence of hair follicles, cutaneous wounds in mice showed delayed reepithelialization but eventually achieved normal wound closure after expanding the activated epidermis region.
research Wnt signaling induces epithelial differentiation during cutaneous wound healing
This study found that manipulating Wnt signaling pathways in cutaneous wounds can induce skin structures resembling regeneration, suggesting a potential role for Wnt signals in restoring skin architecture during wound healing.
research Epithelial‐to‐mesenchymal transition in cutaneous wound healing: Where we are and where we are heading
This review discusses the cellular and molecular changes involved in cutaneous wound re-epithelialization and EMT, highlighting their similarities and differences, but reports no new clinical results.
research Human bone marrow mesenchymal stem cell-derived exosomes stimulate cutaneous wound healing mediates through TGF-β/Smad signaling pathway
In this study, human bone marrow mesenchymal stem cell-derived exosomes significantly accelerated cutaneous wound healing in rats by modulating the TGF-β/Smad signaling pathway.
research Expression and Function of Keratinocyte Growth Factor and Activin in Skin Morphogenesis and Cutaneous Wound Repair
This study reports that overexpression of activin in transgenic mice enhances granulation tissue formation during wound healing, highlighting a novel role for activin in cutaneous repair processes.
research Androgen receptor–mediated inhibition of cutaneous wound healing
This study found that reducing testosterone levels in male mice accelerates wound healing and decreases inflammation, suggesting a potential therapeutic target for improving wound repair in elderly males.
research Hyaluronidase Modulates Inflammatory Response and Accelerates the Cutaneous Wound Healing
In this study, bovine testes hyaluronidase accelerated wound healing in vitro and in vivo by enhancing cellular proliferation, reepithelialization, and modulating inflammation in rat models.
research Recent Advances in the Controlled Release of Growth Factors and Cytokines for Improving Cutaneous Wound Healing
In this review, bioengineered materials incorporating growth factors and cytokines were reported to enhance wound healing by sustaining drug delivery, reducing dosage, and minimizing side effects compared to traditional treatments.
research Tailoring bioinks of extrusion-based bioprinting for cutaneous wound healing
This review discusses extrusion-based bioprinting bioinks for skin regeneration, highlighting their current applications, limitations, and potential improvements, but reports no new experimental findings.
research Recent Advances in Bioengineered Scaffolds for Cutaneous Wound Healing
This review discusses advancements and challenges in bioengineered scaffolds for wound healing but presents no new experimental findings, highlighting their potential and need for further development.
research The role of nuclear hormone receptors in cutaneous wound repair
This review examines the role of nuclear hormone receptors in skin wound repair processes and reports no new clinical results, highlighting the importance of their interaction with skin cells for effective healing.
research Cutaneous Wound Healing in Diabetic Mice Is Improved by Topical Mineralocorticoid Receptor Blockade
research Wnt signaling induces epithelial differentiation during cutaneous wound healing
This review summarizes recent findings on how Wnt signaling proteins play crucial roles in the cutaneous wound healing process but reports no new clinical results.
research Regulatory roles of androgens in cutaneous wound healing
This review discusses how androgens may regulate wound healing and inflammation, noting that testosterone appears to inhibit healing and promote inflammation, but it reports no new clinical results.
research Delayed Cutaneous Wound Healing and Aberrant Expression of Hair Follicle Stem Cell Markers in Mice Selectively Lacking Ctip2 in Epidermis
This study found that the absence of Ctip2 in epidermal keratinocytes led to impaired wound healing in mice, affecting cell migration, proliferation, and hair follicle stem cell maintenance.
research A Modeling Conundrum: Murine Models for Cutaneous Wound Healing
This study highlights the need for standardized preclinical murine models to improve the translation of wound healing research to human clinical applications, specifically noting variations in diabetes duration, animal sex, and assessment methods on healing outcomes in rat models.
research Enhanced cutaneous wound healing by functional injectable thermo-sensitive chitosan-based hydrogel encapsulated human umbilical cord-mesenchymal stem cells
This study found that a newly developed injectable hydrogel combined with human umbilical cord-mesenchymal stem cells significantly accelerated wound healing and reduced inflammation in full-thickness cutaneous wounds.
research Vitamin D Receptor Is Required for Proliferation, Migration, and Differentiation of Epidermal Stem Cells and Progeny during Cutaneous Wound Repair
This study found that the vitamin D receptor is essential for the self-renewal, migration, and differentiation of epidermal stem cells during skin wound healing in mice.
research The potential application of natural products in cutaneous wound healing: A review of preclinical evidence
This review discusses the mechanisms and targets of natural products for treating nonhealing wounds and reports no new experimental results, highlighting potential pathways and cytokines involved.
research Activin B Promotes BMSC-Mediated Cutaneous Wound Healing by Regulating Cell Migration via the JNK—ERK Signaling Pathway
In this study, the researchers reported that activin B combined with bone marrow-derived mesenchymal stem cells enhanced wound healing and hair follicle regeneration in rats by promoting cell migration through the ERK and JNK pathways.
research The Role of Stem Cells in Cutaneous Wound Healing: What Do We Really Know?
This article discusses stem cell-based therapies for wound healing and highlights their potential for tissue repair and regeneration, without presenting new clinical results.
research Pro‐Regenerative Hydrogel Restores Scarless Skin during Cutaneous Wound Healing
This study found that the DexIEME hydrogel promotes complete skin regeneration and scar attenuation in murine and porcine models, suggesting potential for treating deep dermal injuries.
research Sustained Exosome‐Guided Macrophage Polarization Using Hydrolytically Degradable PEG Hydrogels for Cutaneous Wound Healing: Identification of Key Proteins and MiRNAs, and Sustained Release Formulation
In an animal model, this study found that PEG hydrogels delivering M2 macrophage-derived exosomes effectively promoted M1 to M2 macrophage transition and enhanced wound healing.
research Fibromodulin reduces scar formation in adult cutaneous wounds by eliciting a fetal-like phenotype
This study found that fibromodulin significantly reduces scar formation and boosts scar strength in rodent and porcine models, suggesting potential for FMOD-based therapies in cutaneous wound repair.
research Epithelial–Mesenchymal Plasticity and Endothelial–Mesenchymal Transition in Cutaneous Wound Healing
This review discusses the concept of epithelial-mesenchymal plasticity in wound healing and highlights restricting EMT for effective reepithelialization, but reports no new clinical results.
research Improved cutaneous wound healing after intraperitoneal injection of alpha‐melanocyte‐stimulating hormone
This study found that α-MSH administration before skin wounding in adult mice reduced inflammation and scar area, suggesting a potential pathway to more regenerative healing.
research Differential cutaneous wound healing in thermally injured MRL/MPJ mice
This study found that MRL/MpJ mice heal burn wounds with scar formation, experiencing delayed wound closure and impaired myofibroblast development, which contrasts with quicker contraction in BALB/c mice.