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research Development and Evaluation of Finasteride Niosomes Targeting Hair Follicles for Androgenic Alopecia Management
Finasteride niosomes were developed and found to be effective in treating hair loss, with better results than commercial minoxidil, and could be a promising topical treatment for hair loss.
research Inhibition of 5α-Reductase Activity in SZ95 Sebocytes and HaCaT Keratinocytes In Vitro
The substance MK386 effectively blocked testosterone conversion and reduced cell growth in certain skin cells, but inhibiting 5α-reductase alone may not greatly improve acne.
research Cloning, Computational Analysis and Expression Profiling of Steroid 5 Alpha-Reductase 1 (SRD5A1) Gene During Reproductive Phases and Ovatide Stimulation in Endangered Catfish, Clarias Magur
The research identified and described a gene important for hormone conversion in endangered catfish, which varies in activity during different reproductive stages and after hormone treatment.
research Age-Dependent Regulation by Androgens of Gene Expression in the Anterior Hypothalamus and Stress-Induced Release of Adrenal Hormones in Adolescent and Adult Male Rats
Testosterone affects stress hormone levels differently in adolescent and adult male rats.
research Assessment of Efficacy and Safety of Dapsone Gel 5% in the Treatment of Acne Vulgaris
Dapsone gel 5% is effective and safe for treating acne.
research Dihydrotestosterone Induces Proliferation, Migration, and Invasion of Human Glioblastoma Cell Lines
Dihydrotestosterone increases growth and spread of human brain cancer cells, and blocking its formation might help treat this cancer.
research Management of Neonates and Children with Male Pseudohermaphroditism
Individuals with male pseudohermaphroditism often do better raised as females with early surgery.
research Minoxidil Increases 17β-Hydroxysteroid Dehydrogenase and 5α-Reductase Activity in Cultured Human Dermal Papilla Cells from Balding Scalp
Minoxidil boosts enzymes that help hair growth.
research Effect of Petroleum Ether and Ethanol Fractions of Seeds of Abrus Precatorius on Androgenic Alopecia
The seeds of Abrus precatorius, when processed, can prevent hair loss more effectively than common treatments.
research The Effect of Finasteride in Men with Benign Prostatic Hyperplasia
Finasteride effectively treats BPH but may increase sexual dysfunction risk.
research The Extract of Thuja Occidentalis Semen Inhibited 5α-Reductase and Androgenetic Alopecia in B6CBAF1/J Hybrid Mice
Thujae occidentalis semen extract may help treat male pattern baldness by blocking a hair loss-related enzyme and reducing hair loss in mice.
research A Cornerstone of Hematological Science
The document concludes that accurately identifying leukemia types is crucial, and the risks of cancer from finasteride need careful evaluation against its benefits.
research Aromatase Inhibitors Induce Male Pattern Hair Loss in Women
Aromatase inhibitors cause male pattern hair loss in women.
research Male Alopecia, Finasteride, and Cancer Risk
Finasteride for hair loss may increase the risk of certain cancers and has side effects; better regulation and education on its use are needed.
research Hair Follicles and Associated Glands as Androgen Targets
Androgens like testosterone affect hair growth and oil production differently across body parts and individuals.
research Aromatase Inhibition by Letrozole Attenuates Kainic Acid-Induced Seizures but Not Neurotoxicity in Mice
Letrozole reduces seizures but not brain damage in mice.
research Male Breast Cancer After Finasteride Therapy for Benign Prostate Hyperplasia
A man developed male breast cancer after four years of finasteride treatment for an enlarged prostate.
research Spironolactone Therapy for Hirsutism in a Hyperandrogenic Woman
Spironolactone may help reduce excessive hair growth in women with high male hormone levels.
research 5-Alpha-Reductase Deficiency in a Saudi Girl
A Saudi individual initially identified as a girl had a genetic disorder affecting gender development.
research Forthcoming Issues
White wax and its policosanol boost hair growth better than finasteride.
research Treating Psychogenic Nonepileptic Seizures: Easier Said Than Done
Progesterone treatment improved seizures in a woman with menstrual cycle-related epilepsy, but a wrong medication worsened her condition.
research Effect of 5α-Dihydrotestosterone and Testosterone on Apoptosis in Human Dermal Papilla Cells
High levels of testosterone and 5α-DHT can lead to cell death in cells important for hair growth.
research Transcriptomic Profiling in Silurana Tropicalis Testes Exposed to Finasteride
Finasteride affects frog testes by increasing testosterone, decreasing 5α-DHT, and impacting genes related to reproduction and other functions.
research Contribution of Androgens to Chronic Allograft Nephropathy Is Mediated by Dihydrotestosterone
Male hormones worsen kidney transplant damage, but blocking them helps.
research The Effects of Androgens on T Cells: Clues to Female Predominance in Autoimmune Liver Diseases
Androgens may influence T cells, contributing to higher autoimmune liver disease risk in women.
research Species Differences in Prostatic Steroid 5α-Reductases of Rat, Dog, and Human
Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.
research Biology of Hair Growth
Testosterone and dihydrotestosterone affect hair growth, and new techniques like the folliculogram help study it, but fully understanding hair growth is still complex.
research A Review on Steroidal 5α-Reductase Inhibitors for Treatment of Benign Prostatic Hyperplasia
New treatments for enlarged prostate are being developed, some of which may be more effective than current medications.