Management of Neonates and Children with Male Pseudohermaphroditism

December 1977 in “ Journal of pediatric surgery ”

Patricia K. Donahoe, John D. Crawford, W. Hardy Hendren

testosterone dihydrotestosterone androgen-binding protein male pseudohermaphroditism DHT

TLDR Individuals with male pseudohermaphroditism often do better raised as females with early surgery.

In 1977, a study treated 25 patients with male pseudohermaphroditism, identifying causes such as inadequate testosterone production, incomplete conversion of testosterone to dihydrotestosterone, and insufficient androgen-binding protein at the target cell. The study emphasized the importance of early diagnosis to determine the most suitable gender role for the patient, noting that a change in gender assignment later in life could be disastrous. The researchers concluded that individuals with male pseudohermaphroditism often cope better when raised in the female role, especially if they have incomplete internal structures, and generally recommended that most should be raised as females with appropriate surgical alterations performed at an early age.

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