36 citations
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November 1990 in “The Journal of Dermatology” This study found that dermal papilla cells in culture may enhance and attract follicular epithelial cell growth, suggesting their pivotal role in hair and follicle development.
This study found that co-culturing adipose-derived stem cells with hair follicle-derived melanocytes, combined with narrowband UVB, significantly improved pigmentary response in treating stable, resistant vitiligo compared to non-UVB treatments.
September 2019 in “Journal of Investigative Dermatology” This study found that co-culturing dermal papilla cells in a 3D structure with adipose-derived stem cells may enhance the expression of hair inductivity markers compared to 2D cultures.
7 citations
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December 1991 in “Annals of the New York Academy of Sciences” Dermal papillae are crucial for hair growth and maintenance.
48 citations
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March 2020 in “Stem Cell Research & Therapy” This study found that human adipose-derived stem cells co-cultured on a collagen sponge scaffold showed increased differentiation into keratinocytes, suggesting potential for improved skin wound healing.
17 citations
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August 2020 in “Stem Cell Research & Therapy” This study found that a 3D co-culture of endothelial colony-forming cells and adipose-derived stem cells restored stem cell properties and improved healing in a mouse model of chronic injury.
January 2024 in “Biomaterials Research” This study introduced a novel 3D co-culture system that effectively mimics in vivo extracellular matrix dynamics, supporting hair follicle biology research and providing a robust platform for evaluating hair loss treatments through enhanced epithelial-mesenchymal interactions.
July 2020 in “Research Square (Research Square)” This study found that a 3D co-culture of adipose-derived stem cells and endothelial colony forming cells restored stem cell properties and enhanced wound healing in a mouse model.
18 citations
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January 1994 in “Skin Pharmacology and Physiology” This study observed that in vitro cocultures of hair follicle cells with dermal fibroblasts or hair papilla cells enhanced proliferation and differentiation of outer root sheath cells but did not mimic hair-type differentiation.
14 citations
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September 2018 in “Biochemical and Biophysical Research Communications” This study suggests that co-culturing human outer root sheath cells with human dermal papilla cells can restore their ability to induce hair growth by altering gene expression through paracrine signaling.
December 2025 in “Advanced Healthcare Materials” This study introduces a spherical skin model that effectively mimics key features of human skin, offering a scalable and rapid alternative for non-animal dermatological and cosmetic testing.
October 2021 in “Journal of Investigative Dermatology” In this research, investigators used in vitro models to study the Merkel cell-neurite complex and reported that mechanical stimulation, similar to gentle touch, can induce molecular changes that are potentially relevant to hair growth, thus contributing to the understanding of its underlying mechanisms.
December 2015 in “Vascular Pharmacology” Hair papilla cells are crucial for blood vessel development in hair follicles, affecting hair growth and loss.
11 citations
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February 2020 in “Journal of Biomaterials Science Polymer Edition” This study explored the development of GelMet, an electrospun hybrid nanofiber scaffold made from gelatin and PEG methacrylate, which demonstrated strong mechanical properties and effectively supported cell growth in vitro, suggesting its potential for skin tissue engineering applications.
64 citations
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August 2007 in “Artificial Organs” This study found that PHBV cocultured with epithelial and dermal cells might enhance early-stage wound healing by promoting wound closure and re-epithelization more effectively than PHBV/collagen.
4 citations
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July 2022 in “Annals of translational medicine” This study successfully developed 3D hair follicle organoids from neonatal mouse epidermal and dermal cells, showing structural and molecular resemblance to native anagen hair follicles.
30 citations
,
July 1998 in “British Journal of Dermatology” This study found that in a rat skin model, fat cells inhibited the proliferation of organoid hair follicle cells and fibroblasts but may have accelerated hair follicle cell differentiation.
9 citations
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August 2017 in “Photochemistry and Photobiology” This study found that isolated red light may serve as an alternative for photo-immunotherapy without additional photosensitizers, as it did not reduce keratinocyte differentiation markers or increase photo-oxidative damage, unlike treatment with IL-4 or UVA1/blue light.
1 citations
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January 2003 Merkel cells likely attract sensory nerve fibers.
June 2020 in “Journal of Investigative Dermatology” This study observed that human primary adult hair matrix keratinocytes may have the potential to generate hair follicle organoids, suggesting possible applications in hair follicle neogenesis and preclinical hair growth agent screening.
January 2000 in “Neuroscience Research” 
7 citations
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December 2015 in “Experimental Dermatology” The study found that Sh-Polypeptide 9, a biomimetic peptide, enhances endothelial tubulogenesis and VEGF production more effectively than minoxidil, particularly at low concentrations, suggesting potential for hair follicle vascularization.
68 citations
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March 2008 in “Experimental dermatology” This study introduced a novel in vitro assay for tracking melanosome transfer between melanocytes and keratinocytes, facilitating the quantification of melanin transfer and supporting the role of filopodia as a conduit.
11 citations
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August 1995 in “Journal of Investigative Dermatology” 
4 citations
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August 2017 in “Cosmetics” This study observed that Biota orientalis L. leaf extract may promote hair growth and suppress sebum production in human cells, suggesting potential benefits for hair restoration.
2 citations
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January 2019 in “Methods in molecular biology” This protocol demonstrates that pharmacological inhibition of TGF-β signaling can enhance the proliferative capacity of mouse and human keratinocytes, facilitating their use in skin research and graft preparation.
3 citations
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September 2018 in “Journal of Biomaterials Science, Polymer Edition” This study found that pyramidal neural precursors best grew neurites on matrigel, while neural stem cells differentiated directionally on aligned fibrin, suggesting the importance of biomaterial selection for cell culture.
7 citations
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June 2021 in “Cell Proliferation” This study found that direct interactions between human dermal papilla cells and melanocytes under low oxygen conditions improved cell functions and could be important for hair regeneration efforts.
November 2022 in “Journal of Investigative Dermatology” This study found that non-balding dermal papilla cells emphasized extracellular matrix organization and reduced inflammation when cultured in 3D or with adipose-derived stem cells, unlike balding cells which maintained inflammatory pathways.
June 2017 in “Journal of The American Academy of Dermatology” LED light helps hair follicle cells grow and prevents them from dying by activating certain cell pathways.