Would You Recognize This Lesion as a Gumma Syphilitica?

    June 2017 in “ Journal of The American Academy of Dermatology ”
    Image of study
    TLDR LED light helps hair follicle cells grow and prevents them from dying by activating certain cell pathways.
    The document presents a study investigating the effects of light-emitting diode (LED) light on human outer root sheath cells (hORSCs), which are important for hair follicle structure and hair growth. The study aimed to determine how different wavelengths of LED light affect hORSC proliferation, migration, and apoptosis. The researchers used MTT and migration assays to examine cell proliferation and migration, and real-time PCR and Western blot assays to analyze the expression of molecules related to the Wnt/ß-catenin and ERK signaling pathways, as well as hair stem cell markers and various growth factors. The results showed that low-level LED light irradiation promoted hORSC proliferation, suppressed apoptosis, and induced the expression of Wnt5a, Axin2, Lef1 mRNA, and ß-catenin protein. Additionally, phosphorylation of ERK, c-Jun, and p38 was observed, and LED-irradiated hORSCs increased the proliferation of human dermal papilla cells (hDPCs) in co-culture. The study concluded that LED light irradiation stimulates hORSC proliferation and migration, and inhibits apoptosis through the activation of the Wnt5a/ß-catenin and ERK signaling pathways. No commercial support was identified for this study.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 193 results

      community Why is human evolution like this 😂

      in Chat 2 years ago
      Why androgenic alopecia affects the scalp rather than other body parts, potential explanations for this phenomenon, treatments available to combat hair loss, and the implications of male attractiveness in modern society.

      community Verteporfin and Microneedling

      in Treatments 5 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

    Similar Research

    5 / 1000+ results