Wnt/B-Catenin and ERK Pathway Activation: The Possible Mechanism of Various Light-Emitting Diode Light Regulates the Proliferation of Human Outer Root Sheath Cells

May 2017 in “ Journal of The American Academy of Dermatology ”

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Wnt/ß-catenin ERK pathway LED light human outer root sheath cells hORSCs hair follicle hair growth MTT assay migration assay real-time PCR Western blot Wnt5a Axin2 Lef1 mRNA ß-catenin protein phosphorylation of ERK c-Jun p38 hair stem cell markers CD34 CD200 red light treatment IL-6 IL-8 TNF-a IGF-1 TGF-ß1 VEGF mRNA human dermal papilla cells hDPCs apoptosis Wnt/beta-catenin outer root sheath cells PCR Lef1 beta-catenin ERK phosphorylation red light TNF-alpha TGF-beta1 VEGF dermal papilla cells

Studysummary LED light helps human hair root cells grow and prevents them from dying by activating specific growth pathways.

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