Assessment of the Induction and Morphogenic Potential of Human Hair Matrix Cells and Dermal Papilla Fibroblasts Ex Vivo

    September 2019 in “ Journal of Investigative Dermatology ”
    Ilaria Piccini, K. Bakkar, C. Collin-Djangoné, Ewan A. Langan, Jennifer Gherardini, Ralf Paus, Marta Bertolini
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    TLDR Human hair matrix cells and dermal papilla fibroblasts can form early hair follicle structures but don't produce hair shafts yet.
    In 2019, a study was conducted to assess the potential of dermal papilla fibroblasts (DPs) and primary human adult hair matrix cells (HMx) in hair follicle (HF) morphogenesis. The researchers injected a mixture of labeled HMx and DP cells into human scalp skin and cultured it ex vivo. The cells proliferated for at least 3 days and were detectable in the dermis for 10 days. By day 6, HMx stopped proliferating but did not undergo apoptosis, indicating differentiation. The team also created in vitro self-aggregated DP spheroids that, when co-cultured with HMx, resulted in the formation of HF organoids. These organoids, when placed in human skin, showed HMx cell proliferation and differentiation. However, hair shaft production was absent, suggesting a longer culture period may be needed for fully formed HFs. This preliminary data suggested a potential new application for regenerative medicine technology in hair loss disorders and wound healing.
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