Assessment of the Induction and Morphogenic Potential of Human Hair Matrix Cells and Dermal Papilla Fibroblasts Ex Vivo

    September 2019 in “ Journal of Investigative Dermatology ”
    Ilaria Piccini, K. Bakkar, C. Collin-Djangoné, Ewan A. Langan, Jennifer Gherardini, Ralf Paus, Marta Bertolini
    Image of study
    TLDR Human hair matrix cells and dermal papilla fibroblasts can form early hair follicle structures but don't produce hair shafts yet.
    In 2019, a study was conducted to assess the potential of dermal papilla fibroblasts (DPs) and primary human adult hair matrix cells (HMx) in hair follicle (HF) morphogenesis. The researchers injected a mixture of labeled HMx and DP cells into human scalp skin and cultured it ex vivo. The cells proliferated for at least 3 days and were detectable in the dermis for 10 days. By day 6, HMx stopped proliferating but did not undergo apoptosis, indicating differentiation. The team also created in vitro self-aggregated DP spheroids that, when co-cultured with HMx, resulted in the formation of HF organoids. These organoids, when placed in human skin, showed HMx cell proliferation and differentiation. However, hair shaft production was absent, suggesting a longer culture period may be needed for fully formed HFs. This preliminary data suggested a potential new application for regenerative medicine technology in hair loss disorders and wound healing.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community This serum outperformed Minoxidil in a recent study. Please debunk

       23 upvotes 5 years ago
      A topical solution called "Multi-Peptide Serum for Hair Density" by The Ordinary Company, which contains several ingredients that are used in alternatives to Minoxidil and was found to have better results than 5% Minoxidil in a study. People who have tried it shared their experiences with the serum as well.

      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  743 upvotes 2 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

      community This is the best time in human history to be fighting hair loss

      in Treatment  193 upvotes 2 years ago
      This conversation discusses the advancements in treatments for hair loss, including finasteride, dutasteride, minoxidil and new promising treatments such as pyrilutamide and verteporfin. Other treatments discussed were taking minoxidil orally, tretinoin to turn non-responders into responders and microneedling to further boost growth.

      community Comprehensive Microneedling Guide

      in Microneedling  290 upvotes 2 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

      community Verteporfin and Microneedling

      in Treatments 6 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

    Related Research

    8 / 8 results