This study found that PLX, a mixture of tomato extract and chitooligosaccharide, may reduce prostate weight in testosterone-induced BPH in rats, suggesting it could act as a 5α-reductase inhibitor.
June 2020 in “International journal of research in dermatology” This study found that oral intake of choline-stabilized orthosilicic acid (ch-OSA®) significantly improved hair, skin, and nail health in the Indian population, with no reported side effects.
February 2024 in “Advanced Materials” In this study, researchers discovered that a newly identified oligosaccharide, OG6, promotes hair growth by activating hair follicles, achieved by revealing its hidden activity from a larger molecule structure.
61 citations
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September 2016 in “NPG Asia Materials” This study developed thermo-reversible glycol chitosan hydrogels that effectively form and maintain 3D cell spheroids within one day, offering a simplified method for creating biologically realistic cultures for tissue regeneration and drug screening applications.
4 citations
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March 2022 in “Journal of Cosmetic Dermatology” This study found that formulations containing saccharide isomerate significantly improved scalp flaking, sebum secretion, and transepidermal water loss compared to placebo in an adult Chinese population with dandruff.
7 citations
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August 2024 in “Marine Drugs” This study found that ultrasonically depolymerized ι-carrageenan from Solieria chordalis yields low-molecular-weight fractions that maintain fibroblast viability and show no cytotoxicity, suggesting potential for safe use in human medicine.
6 citations
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September 2024 in “Plant Cell & Environment” This study found that in Arabidopsis root hairs, mild chitosan treatment triggered callose deposition and slowed growth, while a higher concentration inhibited growth without callose deposition, indicating different responses based on chitosan concentration.
2 citations
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November 2025 in “International Journal of Molecular Sciences” This review reports that chitosan, a versatile polysaccharide, shows potential for various therapeutic applications due to its chemical modifications, notably in treating non-communicable diseases and wound healing, though further clinical study is needed to confirm these benefits.
July 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study reports that a low concentration of chitosan induces callose deposition and slows root hair growth in Arabidopsis, suggesting an evolutionary conservation of this response to mild biotic stress across plant types.
19 citations
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January 2019 in “Ginekologia Polska” This study found that combined Myo-inositol and D-chiro-inositol therapy improved metabolic and hormonal parameters, including weight, hormone levels, and skin conditions, in women with PCOS after 6 months.
January 2018 in “Clinical dermatology open access journal” This review discusses the various applications of chitosan-based materials in dermatology and highlights their potential as promising new materials but does not present new experimental results.
4 citations
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September 2020 in “Frontiers in Microbiology” In this study, algal oligosaccharides effectively countered key factors in androgenetic alopecia pathogenesis, improving hair growth indicators in vitro and in mice.
1 citations
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September 2024 in “Progress on Chemistry and application of Chitin and its Derivatives” This review found that insulin-chitosan formulations, such as gels and dressings, show promise in wound healing through anti-inflammatory and antimicrobial effects, although most evidence is from preclinical studies and further research is needed to understand mechanisms.
In this study, chitosan hydrogels and delivery systems showed promise in supporting skin recovery post-laser procedures, enhancing topical treatments for acne and melasma, and improving hair density in scalp applications, but limited study sizes and formulation variability restrict generalizability.
233 citations
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February 2018 in “Polymers” This review examines the roles and benefits of chitosan in cosmetics and oral hygiene, highlighting its potential in the cosmeceutical market, but it reports no new results.
24 citations
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January 2019 in “Science China Life Sciences” Chitosan/LiCl composite scaffolds help heal deep skin wounds better.
23 citations
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January 2016 in “Theranostics” In this animal study, ultrasound combined with a new microbubble formulation of minoxidil increased hair growth rates and improved follicle characteristics more effectively than minoxidil alone.
22 citations
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August 2006 in “Critical Reviews in Plant Sciences” The tropical legume Sesbania rostrata can form nodules in waterlogged conditions using a different method that involves plant hormones and specific genes.
17 citations
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August 2024 in “Discover Nano” This review summarizes that polyesters hold promise for vascular tissue engineering due to their mechanical properties and biodegradability, but optimizing their use in repairing damaged blood vessels remains challenging due to the complexity of vascular tissues.
8 citations
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January 2021 in “Smart materials in medicine” This study found that a newly constructed composite hydrogel dressing, made from silk fibroin, chitosan, and halloysite, promoted hair follicle neogenesis, angiogenesis tissue regeneration, and scar reduction.
1 citations
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January 2017 in “Springer eBooks” This review discusses the role of flavonoids and Nod factors in the symbiosis between legumes and rhizobia and reports no new results; the authors argue this knowledge could enhance sustainable agriculture.
January 2026 in “RSC Advances” The hydrogel helps heal wounds without scars by releasing two drugs gradually.
9 citations
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March 2018 in “Journal of the Formosan Medical Association” In this study, chitosan membranes enhanced melanocyte proliferation and survival by supporting both cell-cell and cell-substrate interactions, unlike polyvinyl alcohol membranes which only facilitated cell-cell interactions.
January 2026 in “International Journal of Biological Macromolecules” The hydrogel improves hair growth treatment by enhancing drug delivery and promoting follicle repair.
26 citations
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September 2023 in “Bioengineered” This review article discusses recent progress in the extraction and potential health benefits of oligosaccharides from brown seaweeds, especially focusing on their antimicrobial, anti-inflammatory, and prebiotic properties, and possible applications in managing metabolic syndrome.
March 2026 in “ACS Omega” This study reported that a novel hydrogel wound dressing, created using a Brachybotrys paridiformis polysaccharide derivative and chitosan, significantly accelerated wound healing and tissue regeneration in vivo, showing nearly complete healing by day 15 compared to controls.
2 citations
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September 2020 in “Swedish Journal of BioScience Research” This study found that chitosan from Lucilia cuprina improved burn healing in diabetic mice, promoting wound closure, epidermal remodelling, and collagen deposition, while also demonstrating antibacterial properties.
June 2023 in “Antioxidants” This study found that lipids extracted from Schizochytrium sp. significantly enhanced the proliferation and survival of dermal papilla cells under oxidative stress, reduced reactive oxygen species, inhibited ferroptosis, and promoted antioxidant genes, which improved hair growth in experimental settings, suggesting a potential treatment for alopecia.
1 citations
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January 2022 This study reported that a combination of Myo-inositol and D-chiro-Inositol improved clinical and laboratory parameters in teenage girls with PCOS compared to a placebo.
April 2025 in “BMC Chemistry” This study developed an organic hair conditioner using chitosan-thiadiazole conjugates that showed improved hair detangling, moisture retention, and protection without causing irritation, promising an environmentally sustainable approach to hair care.