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    Glossary Chemokine

    Chemokines are a family of small signaling proteins that play a crucial role in the immune system by directing the movement of immune cells to sites of inflammation or injury. In the context of hair loss, chemokines can influence hair follicle biology by modulating inflammatory responses and affecting the hair growth cycle. Certain chemokines have been implicated in conditions such as alopecia areata, where immune-mediated attacks on hair follicles lead to hair loss. Their distinguishing characteristic is their ability to bind to specific receptors on target cells, guiding cellular migration and activation.

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    1. Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin Nature Immunology · 2012 · 286 citations
    2. Ovarian leukocyte distribution and cytokine/chemokine mRNA expression in follicular fluid cells in women with polycystic ovary syndrome Human Reproduction · 2006 · 69 citations
    3. The chemokine SDF-1/CXCL12 regulates the migration of melanocyte progenitors in mouse hair follicles Differentiation · 2009 · 57 citations
    4. Identification of Ectodysplasin Target Genes Reveals the Involvement of Chemokines in Hair Development 2012 · 48 citations
    5. Analysis of hidradenitis suppurativa–linked mutations in four genes and the effects of PSEN1-P242LfsX11 on cytokine and chemokine expression in macrophages Human Molecular Genetics · 2018 · 25 citations
    6. Selective Expression of Chemokine Monokine Induced by Interferon-γ in Alopecia Areata Journal of Investigative Dermatology · 2003 · 20 citations
    7. Phosphatase Regulator NIPP1 Restrains Chemokine-Driven Skin Inflammation 2020 · 7 citations
    8. Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study Journal of Clinical Medicine · 2021 · 4 citations
    9. PRF Lysates Modulate Chemokine Expression in Oral Squamous Carcinoma and Healthy Epithelial Cells Bioengineering · 2024 · 2 citations
    10. A meta-analysis of chemokines in alopecia areata: recruiting immune cells toward the hair follicle Frontiers in Immunology · 2025 · 1 citations
    11. Nucleic acid-induced chemokine expression in keratinocytes: Implications for skin inflammation PLoS ONE · 2025
    12. Nucleic acid-induced chemokine expression in keratinocytes: Implications for skin inflammation Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) · 2025
    13. 930 High-fat diet exacerbates neutrophilic folliculitis by facilitating sequential chemokine expressions by keratinocytes and neutrophils 2018
    14. 218 Chemokine receptor CCR5 is the novel target for the treatment of alopecia areata Journal of Investigative Dermatology · 2016
    15. Table 2_A meta-analysis of chemokines in alopecia areata: recruiting immune cells toward the hair follicle.docx Figshare · 2025
    16. Table 1_A meta-analysis of chemokines in alopecia areata: recruiting immune cells toward the hair follicle.docx Figshare · 2025
    17. Image 1_A meta-analysis of chemokines in alopecia areata: recruiting immune cells toward the hair follicle.png Figshare · 2025
    18. Intrinsic Modulators of Hair Growth: Roles of Growth Factors, Cytokines, Chemokines, and Interferons International Journal of Trichology · 2025
    19. Stress-induced chemokine production by hair follicles recruits dendritic cells to sites of minor trauma Journal of dermatological science · 2012
    20. Diagnostic Significance of MIG (Monokine Induced by Gamma Interferon) and IP-10 (Interferon gamma-induced protein 10) Chemokines in Alopecia Areata Medical Science Journal for Advance Research · 2025
    21. Chemogenetic inhibition of Grpr- and/or Npff- expressing spinal neurons in mice suppresses chloroquine-evoked itch, but not signs of mechanical allodynia in a neuropathic pain model ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) · 2026
    22. Th1 Chemokine CXCL10 and Alopecia Areata: The Possible Target for the Treatment of Alopecia Areata Journal of Clinical & Cellular Immunology · 2016 · 3 citations
    23. Unmasking Chemokine‐Inducing Specificity in Oligosaccharide Biomaterial to Promote Hair Growth (Adv. Mater. 6/2024) Advanced Materials · 2024
    24. Platelet-derived chemokines promote skeletal muscle regeneration by guiding neutrophil recruitment to injured muscles Nature Communications · 2023 · 48 citations
    25. Assessment of chemokines MIP-1α and MIP-1 βin Iraqi women with polycystic ovarian syndrome Egyptian Journal of Immunology · 2023 · 1 citations
    26. Common Skin Diseases and Metabolic Syndrome: A Proinflammatory Chemokine Perspective Metabolites · 2026
    27. Chitinase 3-Like 1 and C-X-C motif chemokine ligand 5 proteins and the hair cycle Archives of Dermatological Research · 2024
    28. Alkaline Phosphatase–Regulated C–C Motif Chemokine Ligand 5 (CCL5) Functions as a Critical Mediator of Hair Follicle Neogenesis Tissue Engineering and Regenerative Medicine · 2026
    29. Identification of Distinct Immune Signatures and Chemokine Networks in Scalp Inflammatory Diseases Research Square (Research Square) · 2023
    30. Mining Therapeutic Efficacy from Treasure Chest of Biodiversity and Chemodiversity: Pharmacophylogeny of Ranunculales Medicinal Plants Chinese Journal of Integrative Medicine · 2022 · 8 citations