Functional Genome And Proteome Analyses Of Cutaneous Autoimmune Diseases

The document discussed the application of functional genomics and proteomics technologies to cutaneous autoimmune diseases, including psoriasis, lupus erythematosus, systemic sclerosis, vitiligo, and alopecia areata. It highlighted that gene and protein expression profiles have underscored the importance of cytokines, chemokines, and apoptosis-related molecules in the pathogenesis of these diseases. The findings revealed overlapping gene patterns, suggesting common pathogenic mechanisms among these diseases. However, the document noted that there were still many unresolved questions due to the limited data on local gene expression patterns in affected tissues.