Functional Genome And Proteome Analyses Of Cutaneous Autoimmune Diseases

The document reviewed the application of functional genomics and proteomics in understanding cutaneous autoimmune diseases, including psoriasis, lupus erythematosus, systemic sclerosis, vitiligo, and alopecia areata. It highlighted the importance of cytokines, chemokines, and apoptosis-related molecules in the pathogenesis of these diseases. The findings suggested common pathogenic mechanisms through overlapping gene patterns, although there remained a scarcity of data on local gene expression in affected tissues.