November 2020 in “Bali Medical Journal” PRP may help hair growth in alopecia areata without major side effects, but more research is needed.
4 citations,
December 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” Overactive Wnt signaling in mouse skin stem cells causes acne-like cysts and shrinking oil glands, which some treatments can partially fix.
3 citations,
May 2016 in “Dermatopathology” Lrig1 could be a marker for advanced sebaceous carcinoma.
5 citations,
December 2021 in “Journal of Investigative Dermatology” Hedgehog signaling in certain cells is crucial for hair growth during wound healing.
2 citations,
January 2022 in “Materials today: proceedings” Caffeine may be good for hair growth and skin care because it binds well with keratin.
9 citations,
October 2017 in “Frontiers in plant science” The peach gene CTG134 helps control the interaction between auxin and ethylene, which could lead to new agricultural chemicals.
June 2013 in “International Journal of Dermatology” Central lipohypertrophy in HIV-infected women may lead to shorter eyelashes.
365 citations,
November 2018 in “Journal of Allergy and Clinical Immunology” People with atopic dermatitis have different skin bacteria, and targeting these bacteria might help treat the condition.
38 citations,
January 2017 in “PPAR Research” PPAR-γ helps control skin oil glands and inflammation, and its disruption can cause hair loss diseases.
20 citations,
August 2022 in “Frontiers in Immunology” Fibroblasts are important in healing diabetic wounds, but high sugar levels can harm their function and slow down the healing process.
8 citations,
February 2022 in “Scientific Reports” Medicinal herbs might treat hair loss by affecting genes and pathways related to lipid and glycerophospholipid metabolism.
146 citations,
September 2013 in “Advances in nutrition” Bariatric surgery can cause serious mineral deficiencies, requiring better patient education and monitoring.
176 citations,
February 2006 in “Cancer Research” The study demonstrated that the loss of Patched 1 (Ptch1) function in the basal cell population of mouse skin was sufficient to induce rapid skin tumor formation, similar to human basal cell carcinoma (BCC). The research showed that Ptch1 did not affect the nuclear translocation of β-catenin or activate the Notch pathway, but its absence led to the nuclear accumulation of cell cycle regulators cyclin D1 and B1. This suggested that Ptch1 acted as a tumor suppressor by inhibiting cell cycle progression at the G1-S and G2-M phases, functioning as a "gatekeeper." The mouse model used in this study, due to its high frequency and rapid onset of tumors, was considered ideal for testing therapeutic strategies, including Patched pathway inhibitors.
March 2024 in “Frontiers in genetics” Different types of fibroblasts play specific roles in wound healing and cancer, which could help improve treatments.
November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” Rose stem cell nanoparticles improve skin quality by boosting collagen, aiding cell movement, reducing melanin, and lowering inflammation.
33 citations,
June 2017 in “Developmental Biology” Mice can correct hair follicle orientation without certain genes, but proper overall alignment needs those genes.
3 citations,
February 2022 in “Frontiers in cell and developmental biology” A specific RNA molecule, circCOL1A1, affects the growth and quality of goat hair by interacting with miR-149-5p and influencing cell growth pathways.
3 citations,
December 2021 in “Recent patents on anti-cancer drug discovery” SET7/9 enzyme affects cell growth and diseases like cancer, diabetes, and obesity.
1 citations,
January 2018 in “Elsevier eBooks” The skin's dermal layer contains true stem cells with diverse functions and interactions that need more research to fully understand.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” MPZL3 protein helps keep sebaceous gland size and cell growth in check.
68 citations,
June 2005 in “Expert Opinion on Therapeutic Targets” Oestrogens help maintain healthy skin, heal wounds, and may protect against skin aging and cancer.
14 citations,
May 2017 in “Cell metabolism” Paneth cells and intestinal stem cells work together metabolically for stem cell function and regeneration.
3 citations,
July 2023 in “Biomolecules” B2m-free HLA variants may be a new class of HLA important in immune responses and diseases.
64 citations,
July 2016 in “Cold Spring Harbor Perspectives in Medicine” The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.
54 citations,
August 2019 in “Bioscience trends” Stem cells help repair tissue mainly by releasing beneficial substances, not by replacing damaged cells.
38 citations,
September 2014 in “Cell and Tissue Research” The hair follicle infundibulum plays a key role in skin health and disease, and understanding it better could lead to new skin disease treatments.
6 citations,
May 2021 in “Stem Cell Reviews and Reports” Newly found stem cells in horse hooves show promise for treating a hoof disease called laminitis.
6 citations,
August 2015 in “Journal of Molecular Histology” Caspase-7 has functions in skin and hair that are not related to cell death.
82 citations,
March 2012 in “Development” Drosha and Dicer are essential for hair follicle health and preventing DNA damage in skin cells.
24 citations,
April 2014 in “Oncotarget” Minoxidil can reduce functions related to androgen receptors.