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This study reported that the Computational Analysis of Novel Drug Opportunities platform effectively uses integrated biological data, including side effects and pathways, to generate potential drug candidates for colon cancer and migraine disorders.

This study found that Monascus cursory extraction reduced baldness, prostate hyperplasia, and tumor incidence in animal models of androgen-related diseases, suggesting it may be a promising new therapeutic candidate.

This study analyzed RNA-seq data from various animal breeds and suggested that similar molecular mechanisms may underlie wool fineness in different sheep breeds. Researchers identified 32 candidate genes related to hair follicle regulation, providing insights for molecular breeding and evolutionary studies.

This paper discusses a structure-based analysis to find new BRD4 inhibitors, identifying finasteride and amentoflavone as promising candidates for BET inhibition.

This study analyzed the essential oil from Chamaecyparis lawsoniana and found that it is rich in limonene and exhibits antibacterial and antifungal properties, particularly against Candida albicans and certain Gram-positive bacteria.

This study provides a guideline for the safe and effective use of testosterone in women with hypoactive sexual desire disorder, recommending systemic transdermal testosterone for appropriate candidates while highlighting the importance of informed consent and monitoring due to unestablished long-term safety.

This study found that the WNMFDDA model effectively predicts drug-disease associations, achieving high accuracy in cross-validation and confirming most candidate associations through existing databases.

This study evaluated novel steroid compounds for their ability to inhibit 5α-reductase, showing that compound 16a significantly reduced rat prostate weight more than epristeride and exhibited excellent in vitro inhibitory potency, indicating its potential as a lead candidate for further benign prostatic hyperplasia drug research.

This study found that the plant Clausena anisata exhibited promising antimicrobial, antioxidant, and anti-inflammatory activities against acne-causing bacteria and inflammation, suggesting its potential as a candidate for further anti-acne treatment research.

This study identified differentially expressed proteins and pathways potentially involved in wool bending in Zhongwei goats, with specific genes like COL6A1 and CRNN emerging as important candidates in this process.

This article discusses the philosophy and strategies for dense packing in hair transplantation, emphasizing that not all patients are candidates, and reports no clinical results.

In this study, flat feet were identified as a potential indicator of metabolic syndrome in obese individuals, with significant associations noted for striae distensae and candida intertrigo with abdominal obesity.

This study discovered a potential new 5α-reductase type II inhibitor with higher predicted activity than finasteride, suggesting it as a promising candidate for treating benign prostatic hyperplasia.

This study found that 1,2,3,4-tetrahydroquinoline derivatives, particularly N-methyl-7-amino-1,2,3,4-tetrahydroquinoline, may be excellent blue dye candidates for human hair, offering superior color purity, stability, and fastness compared to 2,3-dihydroindoles.

This study reported the development of new pyrazole-based MPC inhibitors that effectively inhibit mitochondrial pyruvate transport, showing potential as therapeutic candidates for conditions like metabolic dysfunction-associated steatohepatitis without activating PPARγ.

This study found that phenolic compounds from Quercus acutissima, particularly casuarinin, showed strong antioxidative, anti-inflammatory, and antiacne effects in mouse macrophage cells, suggesting potential therapeutic candidates for acne.

This study found that cortexolone 17α-propionate (clascoterone) effectively inhibited androgen receptor-regulated transcription and IL-6 synthesis in scalp cells, potentially making it a promising candidate for topical treatment of androgenetic alopecia.

In this study, the researchers noted that approximately 15% of hair transplant procedures are performed on women, with candidacy being determined by specific anatomical conditions and hair loss types, such as medium-stage androgenetic alopecia or a high frontal hairline.

This study described the clinical course of six young patients with type 1 autoimmune polyglandular failure, all of whom initially presented with hypoparathyroidism followed by mucocutaneous candidiasis and adrenal failure.

In this study, researchers found that a specific Sargassum horneri extract processed via low-temperature pulverization improved burn wound healing in mice by enhancing re-epithelialization and reducing inflammation and oxidative stress, highlighting its potential as a therapeutic candidate.

This theoretical study suggests that certain cannabinoid derivatives could potentially be effective as androgen receptor and 5α-reductase enzyme inhibitors, indicating they may be promising candidates for prostate cancer treatment based on their higher affinity to target proteins compared to standard drugs.

This review discusses the potential medicinal properties and pharmacokinetic features of nettle compounds ursolic acid and quercetin, highlighting quercetin as a promising candidate for antioxidant and anti-aging effects, but reports no new clinical results.

This study found that chitosan nanoparticles containing Cordyceps militaris effectively reduced lung damage in mice exposed to fine particulate matter (PM2.5) by decreasing oxidative stress and preserving lung barrier integrity, suggesting potential as a therapeutic candidate for PM2.5-induced lung diseases.

This study concluded that Metformin may be suitable for prophylaxis or mild COVID-19, while a combination of Oseltamivir, Tamoxifen, and Dexamethasone could benefit moderate to severe cases, highlighting the need for more trials on other drug candidates.

This study identified 1277 genomic regions selected for traits in indigenous Chinese goats, including cashmere fiber, reproduction, size, and high-altitude adaptation, revealing key candidate genes for these phenotypes through whole-genome resequencing.

In laboratory experiments, this study found that the topical prodrug SCD-153, a derivative of 4-methyl itaconate, reduced inflammation-related gene expression and induced significant hair growth in mice, suggesting it as a promising treatment candidate for alopecia areata.

This preliminary study found that Melandrium firmum extract may promote hair growth and inhibit 5α-reductase, suggesting potential as a candidate for treating androgenetic alopecia.

This study developed a high-throughput method that identifies bioactive chemicals influencing DHT production in prostate cancer cells, with potential nutraceutical candidates including fucoxanthin, phenethyl caffeate, and Curcuma longa L. extract.

This study identified key genes linked to immune cells and potential therapeutic compounds for alopecia areata by evaluating upregulated genes from patient datasets, highlighting T and NK cell involvement in hair follicle attack and suggesting drug candidates through molecular docking and dynamics simulations.

In this study, OEA was found to significantly enhance sebaceous lipogenesis and potentially reduce inflammation in human sebocytes, suggesting it as a promising candidate for treating skin dryness.