January 2021 in “Natural Products Chemistry & Research” This study found that Datura metel leaf and flower extracts could improve hair growth, with leaf extracts prompting quicker growth and mixed extracts enhancing overall regrowth effectiveness in animal models.
In this animal study, leaf extracts of Kalanchoe pinnata increased hair length in rabbits in a concentration-related manner, surpassing minoxidil at the highest concentration, though hair mass was unaffected.
1 citations
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June 2025 in “Pharmacognosy Research” This study found that a polyherbal sunscreen cream, F4, containing Camellia sinensis, Vitis vinifera, and Silybum marianum extracts demonstrated strong antioxidant and photoprotective properties, similar to synthetic sunscreens.
This study found that an extract treatment showed similar efficacy and tolerability to calcipotriol/betamethasone ointment in reducing psoriasis severity and symptoms over 28 days in patients with mild-to-moderate plaque psoriasis.
December 2014 in “Research and Reviews: Journal of Pharmacology and Toxicological Studies” This study found that applying pet ether extract of Brassica oleracea to rats' skin promoted earlier and longer anagen phases in hair growth, outperforming 1% minoxidil.
November 2019 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study found that combining 7% chamomile extract with 5% minoxidil solution may reduce cutaneous side effects like itching, scaling, and erythema in male patients with androgenic alopecia, potentially improving treatment compliance.
August 2026 in “Revista Brasileira de Farmacognosia” Sea holly extract may help reduce hair loss.
January 2023 in “Biocell” The study found that safflower extract may help protect human follicle dermal papilla cells from cisplatin-induced damage, suggesting its potential as an adjuvant in chemotherapy to mitigate hair follicle cell damage.
April 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study investigated a herbal hair lotion using natural ingredients like rosemary and fenugreek extracts, finding that the F3 formulation had optimal spreadability, absorbency, washability, and stability, without causing skin irritation.
2 citations
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April 2022 in “Journal of Cosmetic Dermatology” This study found that de-saponinated Camellia seed cake extract promotes hair growth in vitro and in vivo by enhancing dermal papilla cell proliferation and modulating signaling pathways and growth factor expression.
October 2021 in “Journal of Investigative Dermatology” Pink berry extract effectively treats scalp issues from frequent head covering.
6 citations
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July 2023 in “Plants” This study found that Datura metel extracts obtained through supercritical CO2 extraction demonstrated significant biological activity, including antioxidant and anti-inflammatory properties, and effectively promoted wound closure and collagen preservation, comparable to standard treatments, in laboratory experiments.
10 citations
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July 2022 in “Journal of Cosmetic Dermatology” This study suggests that Medicago sativa extract, combined with UVA light, may enhance pigmentation in hypopigmented skin and hair, offering potential treatment for vitiligo.
April 2026 in “SHILAP Revista de lepidopterología” In this study, Myrtus communis leaf extract significantly reduced IL-1α expression and increased VEGF expression in human keratinocytes, which the researchers suggest may be linked to its traditional use in treating hair loss and wound healing. Further investigation is needed to clarify its mechanisms.
5 citations
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August 2018 This paper highlights the growing scientific interest in plant extracts for cosmetics due to their potential benefits, including antioxidant, antimicrobial, and protective properties, while emphasizing the need for quality and safety assessment to mitigate possible adverse reactions.
February 2020 in “International research journal of pharmacy” This study suggests that a topical emulsion containing Camellia sinensis and Allium cepa extracts may show promise for treating alopecia areata in Wistar rats.
1 citations
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May 2025 in “International Journal of Applied Pharmaceutics” This study formulated a nanogel with Bangkal bark extract that showed moderate antibacterial activity against Propionibacterium acnes, with the F3 formulation (8% extract) achieving the highest inhibition zone of 8 mm, suggesting potential as a natural acne treatment.
June 2022 in “Journal of Cosmetic Dermatology” This study found that the ethanolic extract of Acanthus ebracteatus demonstrated potential as an anti-hair loss treatment by promoting dermal papilla cell proliferation, inhibiting 5α-reductase activity, and reducing inflammation in vitro.
June 2026 in “International Journal of Drug Delivery Technology” This study developed EGCG-loaded nanohydrogels using ethyl cellulose and polyvinyl alcohol to enhance the stability and delivery of the hydrophilic drug in aloe vera gel, optimizing encapsulation efficiency and drug release properties.
53 citations
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July 2021 in “International Journal of Molecular Sciences” This study found that extracts from Geranium pyrenaicum show promising antioxidant, enzyme inhibitory, and antiviral activities, particularly the methanolic extract's antiviral activity against HSV-1.
2 citations
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October 2023 in “JURNAL ILMU KEFARMASIAN INDONESIA” In this study, researchers formulated a nanosuspension of kenikir leaf extract that meets physical criteria and exhibits cytotoxic activity against MCF-7 breast cancer cells.
April 2026 in “Clinical Cosmetic and Investigational Dermatology” In this study, exposure to Myrtus communis leaf extract significantly reduced IL-1α expression and increased VEGF expression in human keratinocytes, which may relate to its traditional use for hair loss and wound healing; further research is necessary to understand its mechanisms.
November 2025 in “Naukovij vìsnik veterinarnoï medicini” This study found that applying aqueous bay leaf extract to skin graft wounds in rabbits reduced inflammation and improved tissue regeneration, leading to enhanced healing compared to untreated controls, particularly in terms of collagen organization, fibrosis, and inflammation modulation over a 21-day period.
June 2022 in “Zenodo (CERN European Organization for Nuclear Research)” This study evaluated a hydrogel containing extracts from azadirachta indica and tridax procumbens for treating seborrheic dermatitis, finding it passed various tests, including skin irritation and stability, suggesting potential future applications in herbal formulations.
October 2024 in “JURNAL ILMU KEFARMASIAN INDONESIA” This study found that the F6 formulation of a hair tonic containing EDS and ATG extracts produced the most significant hair growth in rabbits, without causing skin irritation and remaining stable throughout the observation period.
November 2025 in “Essential Chem” In this study, Eclipta alba extract showed potential for hair regrowth by increasing the proliferative activity of human dermal papilla cells by 45% in vitro, with evidence suggesting activation of the Wnt signaling pathway.
April 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study reported the successful formulation and evaluation of a herbal hair lotion using natural ingredients; among tested versions, formulation F3 demonstrated superior spreadability, absorbency, and stability without causing skin irritation.
3 citations
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August 2024 in “Cosmetics” This study found that a 12-week regimen of a botanical supplement significantly improved skin and scalp health in women exposed to high pollution, enhancing factors like skin radiance, moisturization, and reducing wrinkle depth and scalp redness compared to a placebo.
December 2023 in “Polish Journal of Chemical Technology” This study found that Ajuga reptans leaf and root extracts, when incorporated into cosmetic products, improved skin hydration, elasticity, pore size, hyperpigmentation, and wrinkle depth.
April 2022 in “Gugje bogeon mi-yong haghoeji” In this study conducted using an in vitro model with rabbits, researchers found that citral from lemongrass oil, especially at a 1% concentration, improved comedone erythema and tissue hyperplasia, suggesting its potential as a treatment for comedone acne.