Molecular Insights Into the Hair Growth-Promoting Mechanisms of Eclipta Alba

November 2025 in “ Essential Chem ”

Mukul Gangil, Pankaj Sharma, Vinay Jain

Eclipta alba wedelolactone ecliptine Wnt/β-catenin signaling pathway β-catenin VEGF receptors human dermal papilla cells false daisy

Studysummary In this study, Eclipta alba extract showed potential for hair regrowth by increasing the proliferative activity of human dermal papilla cells by 45% in vitro, with evidence suggesting activation of the Wnt signaling pathway. Our plain-language summary of this paper — not a Tressless recommendation.

The study explores the hair growth-promoting mechanisms of Eclipta alba, particularly its ethanol extract, which contains wedelolactone and ecliptine. These compounds enhance the Wnt/β-catenin signaling pathway and show strong binding affinities to β-catenin and VEGF receptors, leading to a 45% increase in the proliferation of human dermal papilla cells. Ethanol was identified as the most effective solvent for extracting these bioactive compounds. The findings suggest E. alba as a promising natural therapeutic for hair regrowth, though further research is needed to confirm its efficacy in humans.

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research Glycogen Phosphorylase Inhibitor Promotes Hair Growth via Protecting from Oxidative Stress and Regulating Glycogen Breakdown in Human Hair Follicles

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In this study, the researchers reported that a newly developed PYGL inhibitor, HTPI, enhanced hair growth in an ex-vivo culture by reducing oxidative damage in hDPCs and inhibiting glycogen degradation in hORSCs, showing potential as a treatment for hair loss comparable to minoxidil.

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Molecular Insights Into the Hair Growth-Promoting Mechanisms of Eclipta Alba

Research cited in this study

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