Effects of Some Medicinal Plant Extracts on Dermal Papilla Cells

June 2022 in “ Journal of Cosmetic Dermatology ”

Vanuchawan Wisuitiprot, Kornkanok Ingkaninan, Wudtichai Wisuitiprot, Jukkarin Srivilai, Panlop Chakkavittumrong, Neti Waranuch

medicinal plant extracts dermal papilla cells Acanthus ebracteatus 5α-reductase testosterone cell cycle S phase G2/M phase LPS IL-1β RAW 264.7 cells plant extracts hair loss treatment 5-alpha-reductase inflammation

TLDR Acanthus ebracteatus extract may help prevent hair loss.

The study investigated the effects of ten ethanolic extracts from various medicinal plants on dermal papilla cells to identify potential anti-hair loss treatments. Among the extracts tested, Acanthus ebracteatus (A. ebracteatus) was found to promote dermal papilla cell proliferation and affect the S and G2/M phases of the cell cycle. Additionally, A. ebracteatus exhibited inhibitory activity against 5α-reductase and testosterone, reducing cell viability in dermal papilla cells. It also significantly inhibited LPS-stimulated IL-1β production in RAW 264.7 cells in a dose-dependent manner. These findings suggest that the ethanolic extract of A. ebracteatus is a promising candidate for anti-hair loss treatment.

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