Effects of Some Medicinal Plant Extracts on Dermal Papilla Cells

June 2022 in “ Journal of Cosmetic Dermatology ”

Vanuchawan Wisuitiprot, Kornkanok Ingkaninan, Wudtichai Wisuitiprot, Jukkarin Srivilai, Panlop Chakkavittumrong, Neti Waranuch

medicinal plant extracts dermal papilla cells Acanthus ebracteatus 5α-reductase testosterone cell cycle S phase G2/M phase LPS IL-1β RAW 264.7 cells plant extracts hair loss treatment 5-alpha-reductase inflammation

Studysummary This study found that the ethanolic extract of Acanthus ebracteatus demonstrated potential as an anti-hair loss treatment by promoting dermal papilla cell proliferation, inhibiting 5α-reductase activity, and reducing inflammation in vitro.

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The study investigated the effects of ten ethanolic extracts from various medicinal plants on dermal papilla cells to identify potential anti-hair loss treatments. Among the extracts tested, Acanthus ebracteatus (A. ebracteatus) was found to promote dermal papilla cell proliferation and affect the S and G2/M phases of the cell cycle. Additionally, A. ebracteatus exhibited inhibitory activity against 5α-reductase and testosterone, reducing cell viability in dermal papilla cells. It also significantly inhibited LPS-stimulated IL-1β production in RAW 264.7 cells in a dose-dependent manner. These findings suggest that the ethanolic extract of A. ebracteatus is a promising candidate for anti-hair loss treatment.

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