Myrtus Communis Leaf Extract Modulates IL-1α and VEGF Gene Expressions in HaCaT Cells: Implications for Hair Loss and Wound Healing

    April 2026 in “ Clinical Cosmetic and Investigational Dermatology ”
    Erkin Pekmezci, Murat Türkoğlu
    Studysummary In this study, exposure to Myrtus communis leaf extract significantly reduced IL-1α expression and increased VEGF expression in human keratinocytes, which may relate to its traditional use for hair loss and wound healing; further research is necessary to understand its mechanisms.
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    Research cited in this study 8

    1. Cosmetopoeia of African Plants in Hair Treatment and Care: Topical Nutrition and the Antidiabetic Connection Diversity · 2024
    2. Mechanism of Action of Herbs and Their Active Constituents Used in Hair Loss Treatment Fitoterapia · 2016
    3. Paracrine Crosstalk Between Human Hair Follicle Dermal Papilla Cells and Microvascular Endothelial Cells Experimental Dermatology · 2015
    4. Review of Pharmacological Effects of Myrtus Communis L. and Its Active Constituents Phytotherapy Research · 2014
    5. Influence of Interleukin-1α on Androgen Receptor Expression and Cytokine Secretion by Cultured Human Dermal Papilla Cells Experimental Dermatology · 2006
    6. Expression of Vascular Endothelial Growth Factor (VEGF) in Various Compartments of the Human Hair Follicle Archives of Dermatological Research · 1998
    7. Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells British Journal of Dermatology · 1998
    8. Cytokines and Growth Factors Influence Hair Growth In Vitro: Possible Implications for the Pathogenesis and Treatment of Alopecia Areata Archives of Dermatological Research · 1996