82 citations,
May 2009 in “BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology” Caffeine penetrates human skin in lab tests similarly to real-life conditions, but actual skin use is still essential for accurate results.
49 citations,
December 2017 in “Journal of pharmaceutical and biomedical analysis” The method effectively detects banned substances in urine for sports antidoping.
35 citations,
June 2017 in “Pharmaceutical research” Researchers developed a model that shows hair follicles increase skin absorption of caffeine by 20%.
8 citations,
April 2020 in “European Journal of Nutrition” Newborns' hair shows how much caffeine their mothers drank during pregnancy.
7 citations,
July 2018 in “International Journal of Applied Pharmaceutics” Chitosan nanoparticles are promising for sustained caffeine delivery through the skin.
18 citations,
July 2009 in “Drug Metabolism and Disposition” Finasteride breakdown products found in bile and urine, helps understand drug safety and effectiveness.
17 citations,
August 2015 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” The study found that urine metabolites M1b or M4 are the best indicators of ATD use in horses, with detection possible up to 77 hours in urine and 28 hours in blood.
16 citations,
August 2014 in “Archives of Pharmacal Research” Special nanoparticles increased skin absorption of hair loss treatments with fewer side effects.
4 citations,
February 2022 in “Journal of Pharmaceutical and Biomedical Analysis” The conclusion is that a new method can measure caffeine and drugs in hair, finding caffeine abusers have 70 times more caffeine than normal, with a proposed cut-off value for abuse.
1 citations,
July 2023 in “Cosmetics” The new shampoo effectively delivers caffeine to hair follicles to help keep hair, especially as people age.
November 2023 in “Journal of Cosmetic Dermatology” The topical treatment with caffeine and Procapil 3% improved male pattern hair loss and was well tolerated after 12 weeks.
June 2023 in “Journal of Pharmaceutical and Health Research” Caffeine hair tonic with 0.001% concentration was more effective in promoting hair growth on guinea pigs.
September 2014 in “Hair transplant forum international” Caffeine, niacinamide, and panthenol may improve hair growth, fullness, and healing when applied to the scalp.
94 citations,
May 2011 in “BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology” Hair follicles greatly increase caffeine absorption through the skin shortly after it's applied.
61 citations,
May 2014 in “International journal of pharmaceutics” Nanocrystals improve skin penetration and stability of caffeine, suggesting a new method for delivering similar substances through the skin.
29 citations,
December 2011 in “British Journal of Dermatology” A new hair treatment with caffeine and other ingredients makes hair thicker and less likely to break.
3 citations,
January 2018 in “International Journal of Cosmetic Science” Hair stiffness increased by 13.2% after caffeine treatment, validating the Stiffness-Angle Law as an effective measurement method.
1 citations,
January 2019 in “Advances in Medical Sciences” The combination of azelaic acid, minoxidil, and caffeine significantly increased the survival of skin flaps by affecting certain body channels and nitric oxide levels.
August 2015 in “Arquivo Brasileiro de Medicina Veterinária e Zootecnia/Arquivo brasileiro de medicina veterinária e zootecnia” Caffeine intake during pregnancy and lactation can cause skin lesions in mother rats and their babies, not linked to cortisol levels.
2 citations,
January 2012 in “International Journal of Trichology” Coffee and tea might help hair growth in balding individuals, but side effects and alternative uses are being considered.
47 citations,
August 2016 in “Fitoterapia” Some herbs and their components might help treat hair loss by affecting various biological pathways, but more research and regulation are needed.
25 citations,
July 2017 in “Archives of Dermatological Research” Herbal products might promote hair growth with fewer side effects, but more research is needed to confirm their safety and effectiveness.
7 citations,
February 2018 in “International Journal of Pharmaceutics” Researchers developed a method to measure drugs in hair follicles and found that both water-loving and fat-loving drugs can be detected after being applied to the skin.
1 citations,
July 2021 in “Chemical & pharmaceutical bulletin/Chemical and pharmaceutical bulletin” Rubbing skin increases absorption of water-soluble drugs from lotions and creams, but not oil-soluble drugs.
1 citations,
May 2021 in “Journal of Cosmetic Dermatology” Cosmetic foam product reduces hair loss and increases hair density in men.
June 2015 in “Biomedical and biopharmaceutical research” The congress showed advancements in skin hydration, barrier function, and safe, effective new cosmetic formulations.
December 2023 in “Biological & pharmaceutical bulletin” IPM enhances skin penetration of hydrophilic drugs.
2 citations,
January 2016 Optimized formulations with specific ingredients can significantly improve skin delivery of topical drugs.
August 2018 in “Jundishapur journal of natural pharmaceutical products” Transfollicular drug delivery can improve medication absorption through hair follicles.
12 citations,
May 2013 in “International Journal of Dermatology” Ethosomes improve black tea extract absorption in hair dye.