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    Glossary C3H/HeJ mouse

    strain with impaired immune response due to TLR4 mutation

    The C3H/HeJ mouse is a specific strain of laboratory mouse that is commonly used in scientific research. This strain is notable for its susceptibility to bacterial infections due to a mutation in the TLR4 gene, which impairs its immune response. Researchers often use C3H/HeJ mice to study immune system function, infectious diseases, and related biological processes.

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    Research 30 of 814

    1. Controlled Delivery of T-box21 Small Interfering RNA Ameliorates Autoimmune Alopecia (Alopecia Areata) in a C3H/HeJ Mouse Model ˜The œAmerican journal of pathology · 2008 · 69 citations
    2. The C3H/HeJ mouse and DEBR rat models for alopecia areata: review of preclinical drug screening approaches and results Experimental dermatology · 2008 · 59 citations
    3. Prevention and treatment of alopecia areata with quercetin in the C3H/HeJ mouse model Cell stress & chaperones · 2011 · 29 citations
    4. Recombinant human hepatitis B vaccine initiating alopecia areata: testing the hypothesis using the C3H/HeJ mouse model Veterinary Dermatology · 2009 · 23 citations
    5. Heat treatment increases the incidence of alopecia areata in the C3H/HeJ mouse model Cell Stress and Chaperones · 2010 · 18 citations
    6. ISID0197 - Quantitative analysis of hair loss in mice utilizing imageJ improves the efficacy evaluation of alopecia areata induction in the C3H/HeJ mouse model 2023
    7. 197 Quantitative analysis of hair loss in mice utilizing imageJ improves the efficacy evaluation of alopecia areata induction in the C3H/HeJ mouse model Journal of Investigative Dermatology · 2023
    8. 080 Mouse models of alopecia areata: C3H/HeJ mice versus the humanized AA mouse model Journal of Investigative Dermatology · 2019
    9. Immunophenotypic Analysis of Alopecia Areata Progression in a C3H/HeJ Mouse Model 2258053 The Journal of Immunology · 2026
    10. 085 Autoantigen screening in C3H/HeJ mouse model of alopecia areata revealed high antigenicity of melanocyte-associated antigen epitopes 2019 · 1 citations
    11. Plasmacytoid dendritic cells as a key player in the initiation phase of alopecia areata-induced C3H/HeJ mouse Journal of Dermatological Science · 2016
    12. Effects of the Lexington LaserComb on hair regrowth in the C3H/HeJ mouse model of alopecia areata Lasers in Medical Science · 2011 · 81 citations
    13. ISID1108 - Comparison of ruxolitinib and a collagen-targeted PTH-based hair cycle stimulant on hair follicle counts and hair growth in the C3H/HeJ engrafted mouse model of alopecia areata. 2023
    14. Melanocyte and gonad activity as potential severity modifying factors in C3H/HeJ mouse alopecia areata Experimental dermatology · 2001 · 30 citations
    15. 042 Characterization of Pathogenic CD8+ T Cells in an adoptive transfer Mouse Model of Alopecia Areata in C3H/HeJ mice Journal of Investigative Dermatology · 2025
    16. 1108 Comparison of ruxolitinib and a collagen-targeted PTH-based hair cycle stimulant on hair follicle counts and hair growth in the C3H/HeJ engrafted mouse model of alopecia areata 2023
    17. Role of Aire and Notch4 Allelic Mutations in Alopecia Areata in C3H/HeJ Mice JID Innovations · 2026
    18. Current Protocols: Alopecia Areata Mouse Models for Drug Efficacy and Mechanism Studies Current Protocols · 2024
    19. Alopecia Areata: Updates from the Mouse Perspective 2013 · 8 citations
    20. Hair follicle-derived mesenchymal stem cells decrease alopecia areata mouse hair loss and reduce inflammation around the hair follicle Stem Cell Research & Therapy · 2021 · 11 citations
    21. Generation of autoreactive CD8 T cell in a mouse model of alopecia areata The Journal of Immunology · 2023
    22. Gene Array Profiling and Immunomodulation Studies Define a Cell-Mediated Immune Response Underlying the Pathogenesis of Alopecia Areata in a Mouse Model and Humans Journal of Investigative Dermatology · 2002 · 114 citations
    23. Promoting Effect of Herbal Extracts Mixtures on Hair Regrowth in C3H/HeJ Mice 2009 · 2 citations
    24. Development of Autoimmune Hair Loss Disease Alopecia Areata Is Associated with Cardiac Dysfunction in C3H/HeJ Mice PLOS ONE · 2013 · 18 citations
    25. Alopecia areata Journal of The American Academy of Dermatology · 2017 · 290 citations
    26. Comparison of Alopecia areata in Human and Nonhuman Mammalian Species Pathobiology · 1998 · 71 citations
    27. Alopecia areata − animal models Clinical and Experimental Dermatology · 2002 · 69 citations
    28. IL-12/IL-23 neutralization is ineffective for alopecia areata in mice and humans 2019 · 20 citations
    29. The aetiology and pathogenesis of alopecia areata Journal of Dermatological Science · 1994 · 17 citations
    30. Third International Research Workshop on Alopecia Areata Journal of Investigative Dermatology · 1999 · 15 citations