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GlossaryBrain-Derived Neurotrophic Factor

protein supporting neuron growth and survival in the brain

Brain-Derived Neurotrophic Factor (BDNF) is a protein that plays a crucial role in the growth, maintenance, and survival of neurons in the brain. It is essential for cognitive functions such as learning and memory, and it also supports the health of existing neurons while encouraging the growth of new ones.

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Control of Human Hair Growth by Neurotrophins: Brain-Derived Neurotrophic Factor Inhibits Hair Shaft Elongation, Induces Catagen, and Stimulates Follicular Transforming Growth Factor Beta 2 Expression

research Control of Human Hair Growth by Neurotrophins: Brain-Derived Neurotrophic Factor Inhibits Hair Shaft Elongation, Induces Catagen, and Stimulates Follicular Transforming Growth Factor Beta 2 Expression

64 citations, March 2005 in “Journal of Investigative Dermatology”

Brain-Derived Neurotrophic Factor (BDNF) slows down hair growth and promotes hair follicle regression.

research Reduced Serum Brain-Derived Neurotrophic Factor in Patients with First Onset Vitiligo

9 citations, December 2014 in “Neuropsychiatric Disease and Treatment”

People with first-time vitiligo have lower levels of a certain brain protein compared to healthy individuals.

research Evaluation of Serum Brain-Derived Neurotrophic Factor to Assess the Association Between Psoriasis and Depression

2 citations, September 2015 in “Journal of the Egyptian Women's Dermatologic Society (Print)”

People with psoriasis and depression have lower BDNF levels, which could help measure depression in those with psoriasis.

research Female Pattern Hair Loss and Negative Psychological Impact: Possible Role of Brain-Derived Neurotrophic Factor

July 2023 in “Dermatology practical & conceptual”

Women with Female Pattern Hair Loss may experience more stress, anxiety, and depression, and have lower levels of BDNF, which could predict the psychological impact.

Psychological Stress Impact on Neurotrophic Factor Levels in Patients With Androgenetic Alopecia and Correlation With Disease Progression

research Psychological Stress Impact on Neurotrophic Factor Levels in Patients With Androgenetic Alopecia and Correlation With Disease Progression

October 2024 in “World Journal of Psychiatry”

Stress worsens hair loss in androgenetic alopecia.

research Multipotent Neural Crest Stem Cell-Like Cells from Rat Vibrissa Dermal Papilla Induce Neuronal Differentiation of PC12 Cells

10 citations, January 2014 in “BioMed research international”

Rat whisker cells can help turn other cells into nerve cells and might be used to treat brain injuries or diseases.

The Plastic and Functional Changes in Hippocampal Neurons During Pregnancy, Delivery, and Postpartum Are Reversed by Offspring Deprivation

research The Plastic and Functional Changes in Hippocampal Neurons During Pregnancy, Delivery, and Postpartum Are Reversed by Offspring Deprivation

August 2020 in “Current psychopharmacology”

Pregnancy and nursing increase certain brain activities in rats, but these changes disappear when the babies are taken away.

research Pathophysiological Mechanisms Implicated in Postpartum Depression

142 citations, January 2019 in “Frontiers in Neuroendocrinology”

Postpartum depression is linked to changes in brain chemicals, inflammation, stress, and certain genes, and can potentially be identified by markers like specific steroids, serotonin levels, and vitamin D levels.

research Epithelial Growth Control by Neurotrophins: Leads and Lessons from the Hair Follicle

99 citations, January 2004 in “Progress in brain research”

Neurotrophins are important for hair growth and could help treat hair loss.

research A Role for p75 Neurotrophin Receptor in the Control of Apoptosis-Driven Hair Follicle Regression

96 citations, October 2000 in “The FASEB Journal”

The p75 neurotrophin receptor is important for hair follicle regression by controlling cell death.

research Stress-Related Skin Disorders

67 citations, July 2016 in “Reviews in Endocrine and Metabolic Disorders”

Stress can worsen skin conditions by affecting hormone levels and immune response.

research Gene Polymorphisms and Serum Levels of BDNF and CRH in Vitiligo Patients

July 2022 in “PLOS ONE”

Certain gene variations and different levels of BDNF and CRH hormones are linked to vitiligo.

research Inhibitory Effects of Polyacetylene Compounds from Panax Ginseng on Neurotrophin Receptor-Mediated Hair Growth

7 citations, January 2017 in “Biological & Pharmaceutical Bulletin”

Certain compounds from Panax ginseng can block proteins that affect hair growth, potentially helping treat hair loss.

research Brain-Derived Nerve Factor and Neurotrophins in Androgenetic Alopecia

10 citations, July 2011 in “British Journal of Dermatology”

Lower growth factors linked to balding in androgenetic alopecia.

The Beneficial Effects of Chick Embryo Extract Preconditioning on Hair Follicle Stem Cells: A Promising Strategy to Generate Schwann Cells

research The Beneficial Effects of Chick Embryo Extract Preconditioning on Hair Follicle Stem Cells: A Promising Strategy to Generate Schwann Cells

5 citations, January 2023 in “Cell proliferation”

Chick embryo extract helps rat hair follicle stem cells potentially turn into Schwann cells, important for the nervous system.

research Therapeutic Potential of Hair Follicle-Derived Stem Cell Intranasal Transplantation in a Rat Model of Ischemic Stroke

8 citations, July 2022 in “BMC neuroscience”

Transplanted hair follicle stem cells improved brain function and reduced damage after a stroke in rats.

research Age-Associated Decrease in GDNF and Its Cognate Receptor GFRα-1 Protein Expression in Human Skin

2 citations, June 2016 in “International journal of experimental pathology”

Human skin has less GDNF and its receptor with age.

research Reawakening GDNF's Regenerative Past in Mice and Humans

1 citations, April 2022 in “Regenerative Therapy”

Activating the GDNF-GFRα1-RET signaling pathway could potentially promote skin and limb regeneration in humans and could be used to treat hair loss and promote wound healing.

research Biomaterials Functionalized with MSC Secreted Extracellular Vesicles and Soluble Factors for Tissue Regeneration

220 citations, March 2020 in “Advanced functional materials”

Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

research Conditioned Media Derived from Mesenchymal Stem Cell Cultures: The Next Generation for Regenerative Medicine

88 citations, January 2019 in “Journal of Tissue Engineering and Regenerative Medicine”

Conditioned media from mesenchymal stem cell cultures could be a more effective alternative for regenerative therapies, but more research is needed.

research Molecular Mechanisms Responsible for Therapeutic Potential of Mesenchymal Stem Cell-Derived Secretome

271 citations, May 2019 in “Cells”

The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.

research Prospect of Stem Cell Conditioned Medium in Regenerative Medicine

298 citations, January 2014 in “BioMed Research International”

Stem cell-derived conditioned medium shows promise for treating various medical conditions but requires standardized production and further validation.

research Novel Therapeutic Approaches in Utilizing Platelet Lysate in Regenerative Medicine: Are We Ready for Clinical Use?

51 citations, March 2019 in “Journal of cellular physiology”

Platelet lysate is a promising, cost-effective option for regenerative medicine with potential clinical applications.

research Hair Growth Inhibition by Psychoemotional Stress: A Mouse Model for Neural Mechanisms in Hair Growth Control

127 citations, December 2005 in “Experimental Dermatology”

Stress can stop hair growth in mice, and treatments can reverse this effect.

Direct Implantation of Hair-Follicle-Associated Pluripotent Stem Cells Repairs Intracerebral Hemorrhage and Reduces Neuroinflammation in Mouse Model

research Direct Implantation of Hair-Follicle-Associated Pluripotent Stem Cells Repairs Intracerebral Hemorrhage and Reduces Neuroinflammation in Mouse Model

3 citations, January 2023 in “PloS one”

Implanting hair-follicle stem cells in mice brains helped repair brain bleeding and reduced brain inflammation.