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    Glossary Brain-Derived Neurotrophic Factor

    protein supporting neuron growth and survival in the brain

    Brain-Derived Neurotrophic Factor (BDNF) is a protein that plays a crucial role in the growth, maintenance, and survival of neurons in the brain. It is essential for cognitive functions such as learning and memory, and it also supports the health of existing neurons while encouraging the growth of new ones.

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    1. Control of Human Hair Growth by Neurotrophins: Brain-Derived Neurotrophic Factor Inhibits Hair Shaft Elongation, Induces Catagen, and Stimulates Follicular Transforming Growth Factor β2 Expression Journal of Investigative Dermatology · 2005 · 64 citations
    2. Histone deacetylase inhibitors promote neurosteroid‐mediated cell differentiation and enhance serotonin‐stimulated brain‐derived neurotrophic factor gene expression in rat C6 glioma cells Journal of Neuroscience Research · 2009 · 35 citations
    3. Reduced serum brain-derived neurotrophic factor in patients with first onset vitiligo Neuropsychiatric Disease and Treatment · 2014 · 9 citations
    4. Serum brain‐derived neurotrophic factor and vitamin D: Two concordant players controlling depression among alopecia areata and vitiligo patients: A case–control study Journal of Cosmetic Dermatology · 2023 · 6 citations
    5. Evaluation of serum brain-derived neurotrophic factor to assess the association between psoriasis and depression Journal of the Egyptian Women's Dermatologic Society (Print) · 2015 · 2 citations
    6. Correlation between serum brain-derived neurotrophic factor level and depression severity in alopecia areata patients International Journal of Health Sciences · 2022 · 1 citations
    7. Assessment of Serum Level of Brain-Derived Neurotrophic Factor (BDNF) In Pediatric Alopecia Areata: A Case - Control Study 2025
    8. Female Pattern Hair Loss and Negative Psychological Impact: Possible Role of Brain-derived Neurotrophic Factor (BDNF) Dermatology practical & conceptual · 2023
    9. Brain-derived nerve factor and neurotrophins in androgenetic alopecia British Journal of Dermatology · 2011 · 10 citations
    10. Association between Serum Brain-derived Neurotrophic Factor and 25-OH Vitamin D Levels with Vitamin D Receptors Gene Polymorphism (rs2228570) in Patients with Autoimmune Thyroiditis and Hypothyroidism Open Access Macedonian Journal of Medical Sciences · 2021 · 7 citations
    11. Psychological stress impact neurotrophic factor levels in patients with androgenetic alopecia and correlated with disease progression World Journal of Psychiatry · 2024
    12. Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors, and p75LNGFR. PubMed · 1998 · 122 citations
    13. Epithelial growth control by neurotrophins: leads and lessons from the hair follicle Progress in brain research · 2004 · 99 citations
    14. A role for p75 neurotrophin receptor in the control of apoptosis‐driven hair follicle regression The FASEB Journal · 2000 · 96 citations
    15. Overexpression of neurotrophin 4 in skin enhances myelinated sensory endings but does not influence sensory neuron number The Journal of Comparative Neurology · 2006 · 34 citations
    16. Inhibitory Effects of Polyacetylene Compounds from <i>Panax ginseng</i> on Neurotrophin Receptor-Mediated Hair Growth Biological & Pharmaceutical Bulletin · 2017 · 7 citations
    17. In vitro Differentiation of Adipose-Derived Stem Cells into Hair Cell-Like Cells in Guinea Pigs Journal of Otology · 2007 · 3 citations
    18. The relationship between psychological distress and neurotrophins in patients with alopecia areata: A crosssectional study TURKDERM · 2025
    19. The study of the altering of cytokines and growth factors secreted by cultured balding dermal papilla cells 2012
    20. Stress-related skin disorders Reviews in Endocrine and Metabolic Disorders · 2016 · 67 citations
    21. Integrative analysis reveals ncRNA-mediated molecular regulatory network driving secondary hair follicle regression in cashmere goats BMC Genomics · 2018 · 50 citations
    22. Investigating the synergic effects of valproic acid and crocin on BDNF and GDNF expression in epidermal neural crest stem cells Acta Neurobiologiae Experimentalis · 2020 · 10 citations
    23. Multipotent Neural Crest Stem Cell-Like Cells from Rat Vibrissa Dermal Papilla Induce Neuronal Differentiation of PC12 Cells BioMed research international · 2014 · 10 citations
    24. The beneficial effects of chick embryo extract preconditioning on hair follicle stem cells: A promising strategy to generate Schwann cells Cell proliferation · 2023 · 5 citations
    25. Progesterone Promotes Anti-Anxiety/Depressant-like Behavior and Trophic Actions of BDNF in the Hippocampus of Female Nuclear Progesterone Receptor, but Not 5α-Reductase, Knockout Mice International Journal of Molecular Sciences · 2025 · 4 citations
    26. 690 Platelet activation during PRP preparation for therapeutic use Journal of Investigative Dermatology · 2024
    27. Gene polymorphisms and serum levels of BDNF and CRH in vitiligo patients PLOS ONE · 2022
    28. The Plastic and Functional Changes in Hippocampal Neurons During Pregnancy, Delivery and Postpartum are Reversed by Offspring Deprivation Current psychopharmacology · 2020
    29. Hair follicle stem cell-derived secretome protects astrocytes in an in vitro ischemia/reperfusion model Anatomy & Cell Biology · 2025
    30. PEGylated Flavonoid Aspasomes as a Brain-Targeted Nano-Vesicular Platform for Enhanced Neuroprotection in Stress-Induced Cognitive Dysfunction AAPS PharmSciTech · 2026