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This study describes a method to create keratin hydrogels with adjustable erosion rates by mixing different ratios of keratose and kerateine, enabling controlled release of therapeutic agents like insulin-like growth factor 1.

This study found that a chitosan, chondroitin sulfate, and hyaluronic acid scaffold improved wound healing in rats by promoting immune-stromal interactions, reducing inflammation, and supporting tissue regeneration with ~91% wound closure by day 17 compared to ~63% in controls.

This article reviews how biomaterials and stem cells could advance regenerative medicine but does not report new results, emphasizing the potential of combining novel biomaterials with stem cells for effective therapies.

This study developed a directional pressure-pump hydrogel delivery platform that enhances wound healing in diabetic mechanically dynamic wounds by targeting antibacterial agents and nanozymes directly to the lesion site, disrupting biofilms, mitigating tissue damage, and supporting proper skin closure and vascular remodeling in animal models.

This review summarizes recent advances in the development of engineered polypeptide-based drug delivery systems for cancer therapy, highlighting their potential to improve treatment efficacy and reduce side effects.

This study developed a bilayer material combining poly(vinyl alcohol) and bacterial cellulose with a gelatin-poly(vinyl alcohol) hydrogel, showing strong potential as a wound dressing due to its good antibacterial properties, cell viability, and sustained drug release.

This study developed in vitro methods to regenerate hair follicles and erector muscles by mimicking their native structures and mechanical conditions, reconstructing hair follicle-like structures and forming muscle-like tissues.

This review discusses recent advances in stimuli-responsive nanoformulations for CRISPR-Cas9 delivery, highlighting their design rationales and potential biomedical applications, but reports no new experimental results.

This review discusses current strategies and materials in tissue engineering for skin regeneration, emphasizing design approaches and suggesting directions for future research; it reports no new clinical findings.

This study demonstrated the potential of newly fabricated epithelial cell scaffolds to enhance hair regeneration, showing promise for future alopecia treatments.

This review explores the application and implications of 3D bioprinting in plastic surgery but reports no new clinical results, emphasizing its potential benefits and challenges for future research.

This review highlights the promise of non-viral gene delivery systems, particularly genosomes, over traditional viral vectors due to enhanced safety and efficiency in therapeutic nucleic acid delivery for genetic diseases like cystic fibrosis and malignancies.

This review summarizes advancements in biomaterial-based encapsulation of probiotics for diverse biomedical uses and reports no new clinical results, while outlining current challenges and future research directions.

This study found that keratin hydrogels extracted from human hair showed potential as biodegradable and biocompatible filler materials, promoting angiogenesis and cell proliferation in rat models.

This review highlights the development and assessment of human-relevant models for cutaneous wound healing, emphasizing that a combination of systems, such as organoid platforms and skin-on-a-chip systems, is necessary to overcome limitations of traditional methodologies and address chronic wound challenges.

This study found that fibronectin nanofiber dressings, made using rotary jet spinning, accelerated wound healing and improved tissue restoration in a full-thickness wound mouse model.

This chapter reviews the use of electrospun matrices in creating tissue-engineered skin substitutes and reports no new clinical results; it emphasizes the need for a cell-friendly microenvironment.

This review highlights how nanotechnology enhances CRISPR-Cas9's potential for cancer treatment by improving delivery and stability, addressing key challenges like immunogenicity and delivery inefficiencies, and discusses recent advancements in stimuli-responsive nanoplatforms for precise genome editing.

In this study, researchers used 3D bioprinting with skin stem cells and specific hydrogels to create artificial skin that successfully promoted complete wound healing and the regeneration of skin structures, including hair follicles and blood vessels, in mice.

This review discusses how polymer- and lipid-based nanostructures can enhance wound healing by addressing issues like microbial contamination and inflammation, though it reports no new clinical results.

This review highlights that injectable biostimulatory agents like poly-L-lactic acid, polycaprolactone, and calcium hydroxyapatite are effective in regenerative aesthetics by enhancing collagen production, stimulating adipogenesis, and improving dermal quality, although further research is needed to standardize protocols and confirm long-term safety and efficacy.

In this study, poly (ɛ-caprolactone)–chitosan–poly (vinyl alcohol) nanofibrous scaffolds used on canine skin wound models were found to significantly accelerate healing rates of excision and burn wounds, without inducing immunogenic reactions.

In this study, researchers developed a programmable system using engineered nanovesicles from hair follicle stem cells to modulate immune responses, which showed promise in precisely controlling inflammation, promoting immune balance, and accelerating wound healing, particularly for infected wounds.

This paper describes the development of unique hydrogel skin scaffolds from plant-derived polysaccharide mixtures that may offer improved biocompatibility and mechanical properties for use in artificial skin.

In this study, researchers developed a custom-designed 3D-printed microscope stage insert for inverted confocal microscopes, enhancing the accessibility of long-term intravital imaging of live cell dynamics in live transgenic mice, particularly in the skin.

This study found that a collagen patch made with fibroblast-derived extracellular matrix (fdECM) extracted from human lung fibroblasts enhanced wound healing by promoting wound contraction, angiogenesis, and skin remodeling in full-thickness skin wound models, including those with diabetic ulcers.

This review discusses how functionalized hydrogels can modulate the microbiome to aid tissue regeneration and infection control, highlighting their potential to deliver therapeutic agents effectively and support beneficial immune responses.

In this study, the Cu-doped bioglass composite dressings showed promising results for wound healing and hair follicle regeneration in vitro, with enhanced fibroblast proliferation and vascular growth.

This editorial introduces a special issue on "In Vitro Models of Human Disease" in DMM, highlighting how these models enhance understanding of disease mechanisms, accelerate drug development, and support personalized treatment strategies.