Injectable Biostimulator in Adipose Tissue: An Update and Literature Review
November 2025
in “
Scientia Pharmaceutica
”
Studysummary This review highlights that injectable biostimulatory agents like poly-L-lactic acid, polycaprolactone, and calcium hydroxyapatite are effective in regenerative aesthetics by enhancing collagen production, stimulating adipogenesis, and improving dermal quality, although further research is needed to standardize protocols and confirm long-term safety and efficacy.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The document reviews the use of injectable biostimulatory agents like PLLA, PCL, and CaHA in regenerative aesthetics, focusing on their ability to stimulate collagen production and adipocyte activity, which improves skin volume, elasticity, and texture. PLLA is noted for its long-term effects on dermal thickness and elasticity, while PCL acts as a scaffold for stem cells, enhancing adipogenesis and dermal remodeling. CaHA provides immediate volumization with long-term benefits. Despite promising results, the review highlights the need for standardized protocols and large-scale studies to confirm the efficacy and safety of these treatments in aesthetic applications.
