Platelet-Rich Plasma in Facial Rejuvenation: A Systematic Appraisal of the Available Clinical Evidence

November 2021 in “ Clinical, Cosmetic and Investigational Dermatology ”

Hong Xiao, Dan Xu, Rui Mao, Minqin Xiao, Fang Yang, Liu Yin

platelet-rich plasma PRP hyaluronic acid lipofilling micro-needling laser-based interventions skin texture skin elasticity wrinkles skin health HA microneedling

From the encyclopedia

Platelet-Rich Plasma →

growth factors taken from your blood and injected into your scalp to stimulate hair

Hyaluronic Acid →

Microneedling →

technique to create small wounds in skin to activate collagen production and hair growth

Studysummary This review evaluated existing studies on platelet-rich plasma for facial rejuvenation and found limited clinical evidence supporting its effectiveness, suggesting that more research is needed to establish its utility. Our plain-language summary of this paper — not a Tressless recommendation.

The document "Platelet-Rich Plasma in Facial Rejuvenation: A Systematic Appraisal of the Available Clinical Evidence" is a systematic review of 36 studies involving 3172 patients, examining the use of Platelet-Rich Plasma (PRP) in facial rejuvenation. The studies showed PRP's potential effectiveness in improving skin texture and elasticity, reducing wrinkles, and promoting overall skin health. PRP was evaluated alone or in combination with other treatments like hyaluronic acid, lipofilling, micro-needling, and laser-based interventions. However, the review highlighted a lack of uniformity in PRP preparation, volume injected, frequency of treatment, and assessment methods across the studies. The authors concluded that more high-quality, randomized controlled trials are needed to validate these findings and establish standardized protocols for PRP treatment in facial rejuvenation.

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Comparison Between Single- Versus Double-Spin Prepared Platelet-Rich Plasma Injection in Treatment of Female Pattern Hair Loss: Clinical Effect and Relation to Vascular Endothelial Growth Factor

research Comparison Between Single- Versus Double-Spin Prepared Platelet-Rich Plasma Injection in Treatment of Female Pattern Hair Loss: Clinical Effect and Relation to Vascular Endothelial Growth Factor

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Both methods improve hair density and thickness; double-spin may be more effective.

research The Physician's Guide to Platelet-Rich Plasma in Dermatologic Surgery Part II: Clinical Evidence

24 citations , November 2019 in “Dermatologic Surgery”

This review evaluates the use of platelet-rich plasma in dermatology, highlighting favorable outcomes in several areas, especially androgenetic alopecia, despite a lack of large randomized controlled trials and consistency in protocols.

The Physician's Guide to Platelet-Rich Plasma in Dermatologic Surgery Part I: Definitions, Mechanisms of Action, and Technical Specifications

research The Physician's Guide to Platelet-Rich Plasma in Dermatologic Surgery Part I: Definitions, Mechanisms of Action, and Technical Specifications

16 citations , November 2019 in “Dermatologic Surgery”

This review examines the current evidence for platelet-rich plasma in dermatology, finding favorable outcomes particularly for androgenetic alopecia, but highlights the need for more rigorous clinical trials and standardized protocols.

research Effect of Platelet-Rich Plasma Injection for Rejuvenation of Photoaged Facial Skin

51 citations , November 2018 in “JAMA Dermatology”

This study found that participant self-assessments suggested greater improvement in the texture and wrinkles of facial skin treated with PRP compared to normal saline, though dermatologist ratings showed no significant difference.

research Problems and Solutions for Platelet-Rich Plasma in Facial Rejuvenation: A Systematic Review

20 citations , October 2018 in “Aesthetic Plastic Surgery”

This review discusses the potential mechanisms of platelet-rich plasma in facial rejuvenation and reports no new clinical results, indicating a theoretical basis for its use in tissue regeneration.

research Evaluating Platelet-Rich Plasma Therapy for Facial Aesthetics and Alopecia

31 citations , April 2018 in “Plastic and Reconstructive Surgery”

This review discusses the use of platelet-rich plasma for facial rejuvenation, acne scarring, and androgenic alopecia and reports positive outcomes but emphasizes the need for standardized preparation and application methods.

Combined Autologous Platelet-Rich Plasma with Microneedling Versus Microneedling with Distilled Water in the Treatment of Atrophic Acne Scars: A Concurrent Split-Face Study

research Combined Autologous Platelet-Rich Plasma with Microneedling Versus Microneedling with Distilled Water in the Treatment of Atrophic Acne Scars: A Concurrent Split-Face Study

106 citations , January 2016 in “Journal of Cosmetic Dermatology”

This study found that adding platelet-rich plasma to microneedling improved outcomes for atrophic acne scars more than microneedling alone, according to both quantitative and qualitative assessments.

research Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth

270 citations , March 2012 in “Dermatologic Surgery”

This study found that autologous platelet-rich plasma increased hair growth potential by enhancing dermal papilla cell proliferation and stimulating key signaling pathways in both cell cultures and mice models.

research The Role of Platelet Plasma Growth Factors in Male Pattern Baldness Surgery

251 citations , October 2006 in “Plastic and reconstructive surgery/PSEF CD journals”

In this study, platelet plasma growth factors from patients' autologous plasma improved follicular unit yield in baldness surgery by 15.1% compared to control areas.