Reprogramming Wound Healing: GAG-Based Bioactive Scaffold Drives Pro-Regenerative Cellular Cross-Talk

March 2026 in “ Journal of Biomedical Materials Research Part B Applied Biomaterials ”

Shrikant Sitaram Kirwale, Ritika Jaiswal, Aniruddha Roy

glycosaminoglycan chitosan chondroitin sulfate hyaluronic acid fibroblast macrophage ECM remodeling M2 macrophage polarization hair follicle regeneration GAG CH-(CS-HA)

Studysummary This study found that a chitosan, chondroitin sulfate, and hyaluronic acid scaffold improved wound healing in rats by promoting immune-stromal interactions, reducing inflammation, and supporting tissue regeneration with ~91% wound closure by day 17 compared to ~63% in controls.

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