May 2016 in “Research opinions in animal & veterinary sciences” In this study, aspartame consumption during gestation in rats was associated with significant histological changes and increased apoptosis in the skin of their neonatal pups.
1 citations
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April 2023 in “World Journal of Urology” In this study, researchers found that using a 5-α reductase inhibitor may reduce inflammation-related cytokines associated with T-helper cell 1 and T-helper cell 2 in prostate tissues after surgery, but it did not affect those related to Th17 cells.
29 citations
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March 2014 in “PloS one” In this study, Astragaloside IV was found to inhibit apoptosis-related pathways in hair follicles of mice, suggesting it may serve as an alternative therapy for hair loss.
January 2023 in “Iranian Journal of Pharmaceutical Research” This study concluded that S. hexaphylla extract may improve androgenetic alopecia by reducing 5α-reductase and androgen receptor levels, inhibiting apoptosis, and promoting keratinocyte proliferation in experimental models.
42 citations
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January 2008 in “Clinical colorectal cancer” In this study, a combination of irinotecan and cetuximab showed varied response rates in metastatic colorectal cancer patients, with manageable skin toxicity that improved quality of life when treated collaboratively by oncology and dermatology teams.
1 citations
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May 2023 in “Frontiers in Pharmacology” This study found that millet seed oil effectively promoted hair growth in a mouse model with testosterone-induced hair growth inhibition, suggesting its potential use in preventing or treating androgenetic alopecia.
1 citations
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January 2020 In this study, researchers found that cepharanthine significantly inhibited the growth of non-small cell lung cancer cells by inducing apoptosis through ROS generation and altering multiple signaling pathways, suggesting potential as a novel lung cancer treatment.
52 citations
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May 2011 in “APOPTOSIS” In this study, cisplatin was found to induce cell death in human hair follicle cells through hydroxyl radical generation and Bcl-2 down-regulation, suggesting potential strategies for preventing chemotherapy-induced alopecia.
3 citations
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January 2023 in “International Journal of Molecular Sciences” This review summarizes current knowledge on the role of heat shock proteins in the pathogenesis of PCOS and their potential implications in developing new treatment strategies, but it reports no new experimental results.
1 citations
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April 2025 in “BMC Veterinary Research” This study found that PSAT1 is a key regulator of cellular survival and regenerative capacity in cashmere goat hair follicle stem cells, highlighting its role in the SHF cycle and its potential as a target to boost cashmere fiber production.
1 citations
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July 2023 in “International Journal of Molecular Sciences” This study found that a hypoxic microenvironment enhanced the proliferation and pluripotency of adipose mesenchymal stem cells, promoting hair follicle formation and upregulating specific growth factors in Arbas Cashmere goats.
This study found that applying an ethanol extract of Prasiola japonica improved hair regrowth, length, and follicular density in testosterone-induced hair loss conditions in mice, while also promoting dermal papilla cell proliferation and reducing dihydrotestosterone production, though effects were less pronounced than those of minoxidil.
68 citations
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January 2013 in “BMC Pharmacology and Toxicology” This study found that glibenclamide exhibited a cytostatic effect on MDA-MB-231 breast cancer cells, potentially mediated through K ATP channels, and enhanced the antiproliferative impact of doxorubicin.
8 citations
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June 2021 in “Frontiers in Bioengineering and Biotechnology” This study investigated the effects of the 60% alcohol extract from Alnus sibirica and its active compound, oregonin, on hair health, observing anti-oxidative and anti-apoptotic benefits in human hair dermal papilla cells exposed to oxidative stress, suggesting potential as natural materials for hair loss prevention.
13 citations
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September 2021 in “Current Issues in Molecular Biology” This study suggests that D-panthenol may promote hair growth by enhancing cell viability, suppressing apoptosis markers, and elongating the anagen phase in human hair follicle cells.
10 citations
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May 2020 in “International Journal of Molecular Sciences” This study suggests that human hair follicles may serve as a model for molecular analysis of ABCA4 gene splice-site variants, facilitating research into the pathogenicity of ABCA4 retinopathies.
7 citations
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May 2022 in “Cancers” This study found that UC.145 influences DKK1 methylation and Wnt signaling in gastric cancer, with implications for patient survival and its potential as a predictive biomarker.
4 citations
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July 2025 in “International Journal of Molecular Sciences” This review discusses Amphiregulin (AREG) as a potential target for treating fibrotic disorders and cancer, highlighting its role in disease progression and promising results in preclinical studies and early trials.
2 citations
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December 2023 in “Stem Cells Translational Medicine” This study found that combining ISX-9 with mesenchymal stem cells enhanced their ability to reduce inflammation and repair lung damage in an acute lung injury model compared to using the cells alone.
July 2024 in “International Journal of Molecular Sciences” This article proposes using the hallmarks of ageing and dysregulated microRNAs to create a molecular morbidity score that could improve prognostication and clinical trial inclusion for patients with multimorbidity.
This study found that Avicennia marina extract significantly increased hair growth in androgenic alopecia patients, suggesting its potential effectiveness by inhibiting 5 alpha-reductase and regulating relevant growth factors.
February 2022 in “Journal of Biomedical Nanotechnology” This study concluded that shikonin, a small molecule derived from herbal extract, promotes wound healing and reduces inflammation in mice by activating the PI3K/Akt signaling pathway.
32 citations
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August 2020 in “American Journal Of Pathology” This study reports that in ovarian high-grade serous carcinoma, overexpressed S100A4 likely promotes epithelial-mesenchymal transition and cancer stem cell properties, affecting tumor behavior through its interaction with NMIIA and mutant p53.
7 citations
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December 2021 in “Pharmaceutics” This review examines the anti-alopecia effects of plant-derived phytochemicals and their mechanisms for promoting hair growth, but it reports no new clinical findings.
2 citations
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March 2022 in “Applied sciences” In this study, Lespedeza bicolor extract was found to enhance dermal papilla cell proliferation and extend the anagen phase in mice, suggesting its potential as a treatment for alopecia.
104 citations
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June 2020 in “Journal of Endocrinology” This study suggests that in rats, maternal hyperandrogenism and insulin resistance lead to activation of ferroptosis in the gravid uterus and placenta, mediated by different molecular and cellular mechanisms.
13 citations
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April 2021 in “International Journal of Molecular Sciences” This study found that the fermented black soybean product GR-SC65 reduced particulate matter-induced cell death and oxidative stress in A549 cells, suggesting potential as a therapeutic agent for lung injury prevention.
1 citations
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December 2023 in “Biomolecules” This review highlights the importance of apoptosis in the hair cycle, particularly its role in hair follicle regression and loss, suggesting that understanding its mechanisms can aid in developing treatments to reduce hair loss and promote hair growth.
February 2025 in “International Journal of Molecular Sciences” This study found that melatonin may enhance hair follicle stem cell viability by downregulating the nuclear receptor RORA, which otherwise inhibits cell proliferation and promotes apoptosis.
January 2022 in “Biomedical Reports” This study suggests that inaudible sound at 30 kHz may promote hair growth and inhibit hair loss signals in human dermal papilla cells, indicating potential as a new treatment for androgenic alopecia.